Functional and quantitative alterations in T lymphocyte subpopulations in acute toxoplasmosis.
Functional and quantitative alterations in T lymphocyte subpopulations in acute toxoplasmosis.
复制标题
急性弓形虫病中 T 淋巴细胞亚群的功能和数量变化。
DOI：
10.1093/infdis/150.5.761
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Remington,JS
中科院分区：
文献类型：
--
作者：
Luft,BJ;Kansas,G;Engleman,EG;Remington,JS
本文报告了23例急性弓形虫感染者对弓形虫的细胞免疫反应。T细胞亚群的减少包括由于急性感染而延长症状的患者中抑制性（Leu 2）T细胞的显著和显著升高，以及无症状淋巴结病患者中辅助性T细胞数量的减少或抑制性细胞数量的增加-或两者兼而有之。淋巴细胞对植物血凝素或美洲商陆有丝分裂原的增殖反应在各组间无显著差异。然而，与慢性感染的对照患者相比，急性感染患者对弓形虫抗原的淋巴细胞反应峰值显著降低。抑郁症的动力学与非Leu 2抑制细胞的诱导一致。这些结果表明，在感染弓形虫期间，T淋巴细胞亚群的数量和T细胞对弓形虫抗原的功能发生了明显的变化。刚地。
The cellular immune response toToxoplasma gondiihas been studied in 23 patients with acute toxoplasma infection. Abnormalities of T cell subpopulations included a marked and significant elevation in suppressor (Leu 2) T cells in patients with prolonged symptoms due to acute infection and either a decrease in the number of T helper cells or an increase in the number of suppressor cells — or both — in patients with asymptomatic lymphadenopathy. There was no significant difference in lymphocyte proliferation to phytohemagglutinin or pokeweed mitogen among the various groups tested. The peak lymphocyte response to toxoplasma antigen, however, was significantly depressed in patients with acute infection compared with that in chronically infected control patients. The kinetics of the depression were consistent with the induction of a non-Leu 2 suppressor cell. These results demonstrate marked quantitative alterations in T lymphocyte subpopulations and functional alterations of T cells to toxoplasma antigen during infection withT. gondii.