Multisystem Inflammatory Syndrome in Children: Examining Emerging Data and Identifying Key Knowledge Gaps.
Multisystem Inflammatory Syndrome in Children: Examining Emerging Data and Identifying Key Knowledge Gaps.
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DOI：
10.1097/pec.0000000000002633
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发表时间：
2022-02-01
影响因子：
1.4
通讯作者：
Balamuth F
中科院分区：
文献类型：
--
作者：
Sartori LF;Balamuth F
儿童多系统炎症综合征（MIS-C）是SARS-CoV-2感染后出现的免疫反应异常综合征，可导致儿童器官功能障碍，包括严重的心血管损害。越来越多的证据支持misc与川崎病不同的临床和实验室特征，misc通常发生在年龄较大的儿童中，具有更突出的胃肠道和神经系统症状，以及实验室检测中增加的炎症、淋巴细胞减少和心脏损伤。然而，关于misc治疗的最佳实践和长期结果的高水平证据是有限的。
Multi-system Inflammatory Syndrome in Children (MIS-C) is a syndrome of abnormal immune response following SARS-CoV-2 infection that can result in organ dysfunction including severe cardiovascular compromise in children. Increased evidence supports a clinical and laboratory profile in MIS-C distinct from Kawasaki Disease, with MIS-C typically occurring in older children and with more prominent gastrointestinal and neurologic symptoms, as well as increased inflammation, lymphopenia, and cardiac injury on laboratory testing. However, high level evidence regarding best practices for treatment and long-term outcomes in MIS-C is limited.