In the proper context: Neuropeptide regulation of behavioral transitions during food searching.
In the proper context: Neuropeptide regulation of behavioral transitions during food searching.
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DOI：
10.1080/21624054.2015.1062971
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Francis MM
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文献类型：
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作者：
Bhattacharya R;Francis MM
神经调节能够对解剖学上固定的神经回路进行瞬时重组，产生交替输出和不同的状态，从而使有机体能够对不断变化的条件做出灵活的反应。我们最近确定了神经肽样蛋白 NLP-12（一种哺乳动物胆囊收缩素 (CCK) 的秀丽隐杆线虫同源物）在控制对食物供应变化的行为反应中的需要。我们发现，nlp-12 的缺失会损害局部食物搜索过程中的转向，而 nlp-12 的过度表达足以诱导身体深度弯曲并增强转向。 nlp-12 仅在 DVA 中间神经元中表达，该中间神经元位于多巴胺能 PDE 神经元的突触后以及前运动神经元和运动神经元的突触前，处于调节感觉运动任务的良好位置。有趣的是，DVA 之前曾参与线虫运动过程中 NLP-12 介导的本体感觉反馈回路。在这里，我们讨论 NLP-12 的调节作用，重点是电路级集成与有关食物可用性的嗅觉信息的潜力。此外，我们提出了 DVA 可以整合不同形式的感觉信息来调节 NLP-12 信号传导并介导运动回路的上下文相关调节的潜在机制。
Neuromodulation enables transient restructuring of anatomically fixed neural circuits, generating alternate outputs and distinct states that allow for flexible organismal responses to changing conditions. We recently identified a requirement for the neuropeptide-like protein NLP-12, a Caenorhabditis elegans homolog of mammalian Cholecystokinin (CCK), in the control of behavioral responses to altered food availability. We showed that deletion of nlp-12 impairs turning during local food searching while nlp-12 overexpression is sufficient to induce deep body bends and enhance turning. nlp-12 is solely expressed in the DVA interneuron that is located postsynaptic to the dopaminergic PDE neurons and presynaptic to premotor and motor neurons, well-positioned for modulating sensorimotor tasks. Interestingly, DVA was previously implicated in a NLP-12 mediated proprioceptive feedback loop during C. elegans locomotion. Here, we discuss the modulatory effects of NLP-12 with an emphasis on the potential for circuit level integration with olfactory information about food availability. In addition, we propose potential mechanisms by which DVA may integrate distinct forms of sensory information to regulate NLP-12 signaling and mediate context-dependent modulation of the motor circuit.