Change in cochlear response in an animal model of otitis media with effusion.
Change in cochlear response in an animal model of otitis media with effusion.
复制标题
渗出性中耳炎动物模型中耳蜗反应的变化。
DOI：
10.1159/000241096
复制
发表时间：
2010
影响因子：
1.6
通讯作者：
Gan,RongZ
中科院分区：
文献类型：
--
作者：
Dai,Chenkai;Gan,RongZ
我们之前的研究证实，中耳炎伴积液（OME）时中耳活动能力降低。中耳功能的变化可能导致耳蜗反应的改变。为了评估OME耳蜗的长期功能，本研究的目的是测量OME豚鼠耳蜗基底膜（BM）的位移。在豚鼠中耳注射脂多糖后3天和14天提取的离体制剂中，测量了BM尖端和基底转动的振动。结果表明，在其特征频率下，顶板和底板对耳道声压的位移敏感性分别降低了25 dB。在两组中，耳蜗增益相对于耳鼓运动也发生了变化。本研究为分析豚鼠OME模型基底膜振动的变化提供了数据。
Our previous studies confirm that middle ear mobility is reduced in the presence of otitis media with effusion (OME). Variations in middle ear function may result in changes in cochlear response in OME ears. With the long-term goal of evaluating cochlear function in OME ears, the aim of this study was to measure the displacement of the basilar membrane (BM) in guinea pig ears with OME. Vibrations of the BM at the apex and basal turn were measured in an in vitro preparation extracted 3 and 14 days after injection of lipopolysaccharide in the middle ear of guinea pigs. The results show that the displacement sensitivity of the BM at the apex and the basal turn to sound pressure in the ear canal was reduced up to 25 dB at their characteristic frequencies, respectively. Cochlear gain with respect to umbo movement was also changed in ears with OME in both groups. This study provides data for analysis of the change of BM vibration in a guinea pig OME model.