X-ray diffraction from bone employing annular and semi-annular beams
X-ray diffraction from bone employing annular and semi-annular beams
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DOI：
10.1088/0031-9155/60/15/5803
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发表时间：
2015-08-07
影响因子：
3.5
通讯作者：
Zioupos, P.
中科院分区：
文献类型：
--
作者：
Dicken, A. J.;Evans, J. P. O.;Zioupos, P.
迫切需要准确、低成本的诊断来识别与个体内骨折的高风险相关的骨组织。为了满足这一要求，骨特征的量化，如“骨质量”，需要超过目前提供的密度测定。骨矿物质化学和微观结构可以从骨标本的相干X射线散射特征中确定。因此，如果这些签名可以测量，在体内，以适当的准确性，它应该是可能的骨折风险模型内延长条款，以提高骨折risk prediction.In这个初步研究中，我们提出了一个新的X射线衍射技术，采用空心环形和半环形光束来测量方面的“骨质量”的检查。我们目前获得的衍射图与我们的方法从离体骨标本在Mo K α和W K α能量。对原始数据进行参数化，以提供骨特征的估计值，并指示可以确定这些特征的精度。
There is a compelling need for accurate, low cost diagnostics to identify osteotissues that are associated with a high risk of fracture within an individual. To satisfy this requirement the quantification of bone characteristics such as 'bone quality' need to exceed that provided currently by densitometry. Bone mineral chemistry and microstructure can be determined from coherent x-ray scatter signatures of bone specimens. Therefore, if these signatures can be measured, in vivo, to an appropriate accuracy it should be possible by extending terms within a fracture risk model to improve fracture risk prediction.In this preliminary study we present an examination of a new x-ray diffraction technique that employs hollow annular and semi-annular beams to measure aspects of 'bone quality'. We present diffractograms obtained with our approach from ex vivo bone specimens at Mo K alpha and W K alpha energies. Primary data is parameterized to provide estimates of bone characteristics and to indicate the precision with which these can be determined.