Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder.
Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder.
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DOI：
10.1186/1744-859x-10-26
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发表时间：
2011-09-30
影响因子：
3.7
通讯作者：
Masaomi I
中科院分区：
文献类型：
--
作者：
Tadokoro S;Kanahara N;Kikuchi S;Hashimoto K;Masaomi I
有新的证据表明，抗抑郁药可能有效地预防非特异性和精神病样前驱症状的患者，定义为精神障碍超高风险（UHR）患者，从过渡到精神病。然而，这种效应的机制仍然是未知的。我们报告的情况下，一个19岁的日本男子被确定为在UHR的精神病性障碍，其中氟伏沙明（一种抗抑郁药与σ-1受体激动剂）表现出预防作用的精神病样前驱症状。我们的病人的抑郁症状减少，并保持低于缓解的结果，100毫克/天的氟伏沙明治疗。此外，额外剂量的氟伏沙明（50 mg/天）可能直接改善了他的精神病样前驱症状，与其抗抑郁作用无关。氟伏沙明是一种sigma-1受体激动剂，可能通过其神经保护/亲神经作用有效预防UHR精神病患者精神病发作，而不依赖于其抗抑郁作用。
There is emerging evidence that antidepressants may be effective in preventing patients with non-specific and psychotic-like prodromal symptoms, defined as patients at ultra-high risk (UHR) of psychotic disorder, from transitioning to psychosis. However, the mechanism of such an effect is still unknown. We report the case of a 19-year-old Japanese man determined to be at UHR of psychotic disorder in whom fluvoxamine (one of the antidepressants with sigma-1 receptor agonism) showed preventive effects on psychotic-like prodromal symptoms. Our patient's depressive symptoms were reduced and maintained below remission as a result of treatment with 100 mg/day of fluvoxamine. In addition, it is likely that an additional dose of fluvoxamine (50 mg/day) improved his psychotic-like prodromal symptoms directly, independent of its antidepressive effects. Fluvoxamine, a sigma-1 receptor agonist, may be effective in preventing patients at UHR of psychotic disorder from onset of psychosis via its neuroprotective/neurotropic actions, independent of its antidepressive effects.