Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes.
Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes.
复制标题
DOI：
10.1021/acsami.9b00394
复制
发表时间：
2019-03
影响因子：
9.5
通讯作者：
Gavin R. Philips;B. Gleich;Genaro A. Paredes-Juarez;A. Antonelli;M. Magnani;J. Bulte
中科院分区：
文献类型：
--
作者：
Gavin R. Philips;B. Gleich;Genaro A. Paredes-Juarez;A. Antonelli;M. Magnani;J. Bulte
血液和组织的主动和被动电生理特性已被广泛应用于各种临床技术中，以非侵入性地表征解剖学和生理学，并诊断各种病理。然而，这些技术的精度和空间分辨率受到几个因素的限制，包括根据表面电位确定生物参数和信号源的病态逆问题。在这里，我们提出了一种通过将超顺磁性氧化铁负载的红细胞与振荡磁场对齐来非侵入性调节组织电导率的方法。提出了一种由三维亥姆霍兹线圈对和埋入流体通道的电极阵列组成的原型装置。显示了加载的细胞(∼11 mm铁)在12mT的磁场中的对准，并且这种定向重定向分别改变了静止和流动血液的∼5和∼0.5%的电导率，在6-12mT的弱磁场中。电导性的焦点调制可以极大地改进许多基于生物阻抗的检测方式。
The active and passive electrophysiological properties of blood and tissue have been utilized in a vast array of clinical techniques to noninvasively characterize anatomy and physiology and to diagnose a wide variety of pathologies. However, the accuracy and spatial resolution of such techniques are limited by several factors, including an ill-posed inverse problem, which determines biological parameters and signal sources from surface potentials. Here, we propose a method to noninvasively modulate tissue conductivity by aligning superparamagnetic iron oxide-loaded erythrocytes with an oscillating magnetic field. A prototype device is presented, which incorporates a three-dimensional set of Helmholtz coil pairs and fluid-channel-embedded electrode arrays. Alignment of loaded cells (∼11 mM iron) within a field of 12 mT is demonstrated, and this directed reorientation is shown to alter the conductivity of blood by ∼5 and ∼0.5% for stationary and flowing blood, respectively, within fields as weak as 6-12 mT. Focal modulation of conductivity could drastically improve numerous bioimpedance-based detection modalities.