Association of the metastatic phenotype with CCN family members among breast and oral cancer cells
Association of the metastatic phenotype with CCN family members among breast and oral cancer cells
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乳腺癌和口腔癌细胞中转移表型与 CCN 家族成员的关联
DOI：
10.1007/s12079-011-0133-3
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
et al
中科院分区：
文献类型：
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作者：
Ohgawara T.;et al
CCN蛋白家族由具有保守结构特征的六个成员组成。这些蛋白质在细胞的生理学和病理学中发挥多种作用。在CCN家族的病理作用中，最重要和最有争议的一个是它们在癌症的扩展和转移中的作用。到目前为止，许多报告已经独立地描述了每个CCN家族成员的可能作用。在这项研究中，我们全面分析了所有六个CCN家族成员在体外和体内乳腺癌细胞生长，迁移和侵袭中的作用。因此，我们发现CCN 2/CCN 3比率是与高度转移到骨的乳腺癌细胞的转移表型相关的参数。同样的分析，从口腔鳞状细胞癌的细胞系，不转移到骨进一步支持我们的想法。这些结果表明CCN家族成员之间的相互作用在调节癌细胞表型中的功能意义。
The CCN family of proteins consists of six members with conserved structural features. These proteins play several roles in the physiology and pathology of cells. Among the pathological roles of the CCN family, one of the most important and controversial ones is their role in the expansion and metastasis of cancer. Up to now a number of reports have described the possible role of each CCN family member independently. In this study, we comprehensively analyzed the roles of all six CCN family members in cell growth, migration and invasion of breast cancer cells in vitro and in vivo. As a result, we found the CCN2/CCN3 ratio to be a parameter that is associated with the metastatic phenotype of breast cancer cells that are highly metastatic to the bone. The same analysis with cell lines from oral squamous carcinomas that are not metastatic to the bone further supported our notion. These results suggest the functional significance of the interplay between CCN family members in regulating the phenotype of cancer cells.