Carbon dioxide laser plus topical 5-fluorouracil: a new combination therapeutic modality for acral vitiligo
Carbon dioxide laser plus topical 5-fluorouracil: a new combination therapeutic modality for acral vitiligo
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DOI：
10.3109/14764172.2014.1003241
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发表时间：
2015-01
影响因子：
1.2
通讯作者：
H. Mohamed;G. Mohammed;A. H. Gomaa;M. Eyada
中科院分区：
文献类型：
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作者：
H. Mohamed;G. Mohammed;A. H. Gomaa;M. Eyada
摘要背景：肢端白癜风(AV)对治疗耐药。目的：评价二氧化碳(CO2)激光联合5-氟尿嘧啶(5FU)治疗房颤的疗效和安全性。方法：本研究包括68例成人房室综合征患者。将患者随机分为3组，第1组用5FU治疗，第2组用CO2激光治疗，III组用CO2激光加5FU治疗，疗程最长5个月。然后对损伤进行定性和定量评估。结果：III组近一半(49.8%)的皮损达到G4级，6.1%的皮损达到G3级再着色。这一反应在统计学上显著高于其他两组。这在手部和脚部的指周区域没有达到。在治疗过程中或在5FU应用部位疼痛是可以忍受的。暂时性的色素沉着、甲板上的棕色斑点、瘙痒和感染是暂时的副作用；然而，没有检测到Koebner化。结论：先行CO2激光皮肤消融，然后应用5FU治疗房室是一种安全、可耐受的技术，可改善结果，增加患者的依从性。
Abstract Background: Acral vitiligo (AV) is resistant to treatment. Aim: To evaluate efficacy and safety of combining carbon dioxide (CO2) laser and 5-fluorouracil (5FU) in treating AV. Methods: This study included 68 adult patients with AV. After randomly assigning patients into 3 groups, patients in group I were treated using 5FU, group II were treated using CO2 laser, and group III were treated using CO2 laser followed by 5FU for a maximum period of 5 months. The lesions were then evaluated both qualitatively and quantitatively. Results: Almost half (49.8%) of the lesions in group III achieved G4, and 6.1% of lesions achieved G3 re-pigmentation. This response was statistically significantly higher than that in the other two groups. This was not achieved in periungual areas in the hands and feet. The pain was tolerable during sessions or at sites of 5FU application. Transient hyperpigmentation, brownish spot on nail plates, itching, and infection were temporary side effects; however, Koebnerization was not detected. Conclusion: We concluded that prior use of CO2 laser skin ablation, followed by 5FU application for AV is a safe and tolerable technique that improves the outcome and increases patient compliance.