Adjuvant Effect of Silica (Tridymite) on Antibody Production.∗
Adjuvant Effect of Silica (Tridymite) on Antibody Production.∗
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二氧化硅（鳞石英）对抗体产生的佐剂作用。
DOI：
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发表时间：
1962
期刊：
影响因子：
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通讯作者：
Fiokenzo Paronetto
中科院分区：
文献类型：
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作者：
B. Pernis;Fiokenzo Paronetto
将结晶二氧化硅颗粒（直径1-3 μ）静脉注射到家兔和大鼠体内。在0至90天的不同时间间隔，用卵清蛋白或马血清免疫动物。抗体的产生大大提高了硅酸盐处理的动物。二氧化硅和抗原注射之间的间隔时间越长，抗体滴度越高。在二氧化硅处理的动物中观察到更多的含抗体细胞。提示二氧化硅的佐剂作用与R.E.S.中免疫活性细胞的增殖有关。这可能在矽肺的发病机制中起一定作用。
Summary Crystalline silica particles (1-3 μ in diameter) were injected intravenously into rabbits and rats. At various intervals from 0 to 90 days the animals were immunized with ovalbumin or horse serum. Antibody production was greatly enhanced in silicatreated animals. The antibody titer was higher when the interval between silica and antigen injection was longer. Many more antibody-containing cells were observed in silica-treated animals. It is suggested that the adjuvant effect of silica is related to the proliferation of immunologically competent cells in the R.E.S. This might play a role in the pathogenesis of silicosis.