Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient
Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient
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DOI：
10.1097/inf.0000000000002090
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发表时间：
2019-03-01
影响因子：
3.6
通讯作者：
Amit, Sharon
中科院分区：
文献类型：
--
作者：
Averbuch, Diana;Safadi, Rifaat;Amit, Sharon
转录-1缺陷患者的信号换能器和激活器，在接受先前有效的抗真菌治疗时，表现为长期发烧，恶病质，贫血，低白蛋白血症，最终复发衰弱性分枝杆菌骨髓炎。尽管进行了严格的检查和多种抗生素，但病情的进展促使霰弹枪宏基因组学在肝脏样本中发现了腺病毒。Brincidofovir导致了包括骨髓炎在内的完全、持续的临床恢复，这可能归因于腺病毒诱导的免疫失调的逆转。
A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics prompted shotgun metagenomics revealing adenovirus in liver samples. Brincidofovir led to a complete, sustained clinical recovery, including osteomyelitis, probably attributed to reversal of adenovirus-induced immune dysregulation.