Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase?
Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase?
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DOI：
10.1084/jem.20080086
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发表时间：
2009-01-16
期刊：
影响因子：
--
通讯作者：
Gearhart PJ
中科院分区：
文献类型：
--
作者：
Maul RW;Gearhart PJ
Why women are more susceptible to autoimmune diseases is not completely clear, but new data suggest that the hormone estrogen may play an important role. A new study now shows that estrogen activates the expression of activation-induced deaminase (AID), a protein that drives antibody diversification by deaminating cytosine in DNA to uracil. If estrogen increases the level of AID, increased mutations could transform benign antibodies into anti-self pariahs. AID might also contribute to cancer—particularly in breast tissue, which is highly responsive to estrogen—by introducing mutations and strand breaks into the genome.
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