The Prevalence of Human T-Cell lymphotropic Virus Type 1 in Pregnant Women and Their Newborns.
The Prevalence of Human T-Cell lymphotropic Virus Type 1 in Pregnant Women and Their Newborns.
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DOI：
10.5402/2012/975135
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Meshkat M
中科院分区：
文献类型：
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作者：
Hamedi A;Akhlaghi F;Meshkat Z;Sezavar M;Nomani H;Meshkat M
HTLV 1病毒抗体的流行率是在伊朗东北部马什哈德的孕妇及其新生儿中确定的，如本前瞻性横断面研究所示。407名住院分娩的妇女参加了这项研究。采集孕妇静脉血及新生儿脐带血。所有妇女的第一批样本通过ELISA检测HTLV 1血清阳性，并通过PCR方法确认。然后，通过PCR方法确定HTLV 1阳性母亲分娩的新生儿的脐带血样品中HTLV 1的存在。所有HTLV 1阳性婴儿在9-12月龄时再次呼叫，并使用HTLV 1特异性引物对其进行PCR检测。在所有参与研究的妇女中，6人经ELISA检测HTLV 1血清阳性，并经PCR检测证实。对6例HTLV 1阳性孕妇所生新生儿的脐带血标本进行PCR检测，发现HTLV 1抗体。6例9-12月龄婴儿HTLV 1 LTR特异性引物PCR均为阳性，而HTLV 1 TAX特异性引物PCR仅1例阳性。孕妇HTLV 1抗体阳性率为1.5%，母婴垂直传播率为16.6%。
The prevalence of HTLV1 virus antibodies was determined in pregnant women and their neonates in Mashhad, northeast of Iran, as shown in this prospective cross-sectional study. 407 women who were hospitalized for delivery participated in this study. Venous blood sampling of pregnant women and umbilical cord of their neonates was done. The first samples of all women were tested for HTLV1 seropositivity by ELISA test and confirmed by PCR method. Then, the presence of HTLV1 in samples of umbilical cords blood in neonates who were delivered to an HTLV1-positive mother was determined by PCR method. All HTLV1-positive infants were called again at the age of 9–12 months, and PCR test was done using HTLV1-specific primers for them. Of all the participating women, 6 persons were HTLV1 seropositive by ELIZA test which was confirmed by PCR test. HTLV1 antibodies were found in cord blood samples by PCR test in 6 newborns who were born to HTLV1-seropositive women. All the six infants at the age of 9–12 months showed positive PCR results by HTLV1 LTR-specific primers; however, only one of them was PCR positive using HTLV1 TAX-specific primers. The prevalence of HTLV1 antibodies in pregnant women was 1.5%, and the vertical transmission rate to their neonates was 16.6%.