The genetics of ovarian cancer
The genetics of ovarian cancer
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DOI：
10.1053/beog.2002.0296
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发表时间：
2002-08-01
影响因子：
5.5
通讯作者：
Ponder, BAJ
中科院分区：
文献类型：
--
作者：
Pharoah, PDP;Ponder, BAJ
卵巢癌家族史会增加患卵巢癌的风险。我们回顾了文献量化与卵巢癌相关的家族风险，并评估了卵巢癌家族聚集性是由遗传决定的证据。然后，我们描述了已知的高转移率基因，卵巢癌的风险，他们和他们的贡献卵巢癌的家庭和一般人群。然后考虑其他卵巢癌基因存在的证据。
A family history of ovarian cancer confers an increased risk of ovarian cancer. We review the literature quantifying the familial risks associated with ovarian cancer and assess the evidence that the familial clustering of ovarian cancer is genetically determined. We then describe the known high-penetrance genes, the ovarian cancer risks attached to them and their contribution to ovarian cancer in families and in the general population. The evidence for the existence of other ovarian cancer genes is then considered.