Progesterone effects on preterm birth in high-risk pregnancies: a randomized placebo-controlled trial
Progesterone effects on preterm birth in high-risk pregnancies: a randomized placebo-controlled trial
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DOI：
10.1007/s00404-009-1351-2
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发表时间：
2011-03-01
影响因子：
2.6
通讯作者：
Sancak, Ali
中科院分区：
文献类型：
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作者：
Cetingoz, Elcin;Cam, Cetin;Sancak, Ali
本研究的目的是评估阴道黄体酮预防性给药是否会降低高危人群（包括单胎和双胎妊娠）的早产率。这是一项随机、双盲、安慰剂对照研究，纳入了 150 名高危妊娠。危险人群包括既往自发性早产、双胎妊娠和子宫畸形。在妊娠 24 至 34 周期间，每天通过阴道栓剂施用微粉化黄体酮或安慰剂（100 毫克）。我们比较了黄体酮组和安慰剂组的早产和早产发生率。数据通过chi A(2)分析和Fisher精确检验进行比较。安慰剂组和黄体酮组之间的早产率有统计学显着性差异（分别为45.7% vs. 25%；p < 0.05）。安慰剂组中 37 周前分娩的女性 (57.2%) 多于黄体酮组 (40%；p < 0.05)。服用黄体酮还可以减少妊娠 34 周之前的早产。安慰剂组和黄体酮组之间的差异具有统计学意义（24.3% vs. 8.8%；p < 0.05）。然而，安慰剂组和黄体酮组之间的新生儿死亡率没有显着差异。预防性阴道黄体酮可降低高危妊娠的早产率和早产率。
The purpose of this study was to evaluate whether the prophylactic administration of vaginal progesterone would reduce the preterm birth rate in high-risk population including singleton and twin pregnancies.This was a randomized, double blind, placebo-controlled study that included 150 high-risk pregnancies. Risk groups included prior spontaneous preterm birth, twin pregnancy, and uterine malformation. Micronized progesterone or placebo (100 mg) was administered daily by vaginal suppository between 24 and 34 weeks of gestation. We compared progesterone and placebo groups for incidence of preterm labor and preterm delivery. Data were compared by chi A(2) analysis and Fisher exact test.There was a statistically significant difference in the rate of preterm labor between placebo and progesterone groups (45.7 vs. 25%, respectively; p < 0.05). More women delivered before 37 weeks in placebo group (57.2%) than in progesterone group (40%; p < 0.05). Administering progesterone also reduced the preterm birth before 34 weeks of gestation. The difference between placebo and progesterone group was statistically significant (24.3 vs. 8.8%; p < 0.05). However, there was no significant difference in neonatal death between placebo and progesterone groups.Prophylactic vaginal progesterone reduced the rate of preterm labor and preterm delivery in high-risk pregnancies.