Catechins in neuroAIDS.
Catechins in neuroAIDS.
复制标题
神经艾滋病中的儿茶素。
DOI：
10.1007/s13365-012-0126-x
复制
发表时间：
2012
影响因子：
3.2
通讯作者：
Mocchetti,Italo
中科院分区：
文献类型：
--
作者：
Mocchetti,Italo
The introduction of highly active antiretroviral therapy (HAART) against human immunodeficiency virus type-1 (HIV) has improved immune recovery as well as decreased the gravity of neurological signs associated with HIV infection of the central nervous system (CNS)(Ellis et al. 2007). Yet, HAART has not eliminated mild neurocognitive deficits and asymptomatic neurocognitive impairments in AIDS patients (McArthur et al. 2003). Thus, the need of adjunct therapies and new strategies that target specifically HIV-mediated pathology in the CNS is great.The neuropathology of HIV includes neuronal loss as well as reduction of neuronal connectivity, a phenomenon often referred to as synaptic simplification (Ellis et al. 2007), in which both axons and dendrites undergo retraction. While many compounds have been developed to control viral infection, relatively fewer studies have evaluated the ability of drugs to alleviate or prevent the neuropathology of HIV. This
