S-nitrosylation-regulated GPCR signaling.
S-nitrosylation-regulated GPCR signaling.
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DOI：
10.1016/j.bbagen.2011.03.007
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发表时间：
2012-06
影响因子：
3
通讯作者：
Daaka, Yehia
中科院分区：
文献类型：
--
作者：
Daaka, Yehia
G蛋白偶联受体（GPCR）是数量最多且最多样化的细胞表面受体类型，约占整个人类基因组的1%，并传递来自各种细胞外刺激物的信号，这些细胞外刺激物的范围从脂质和肽生长因子到离子和感觉输入。活化的GPCR调节多种靶细胞功能，包括中间代谢、生长和分化以及迁移和侵袭。GPCR含有特征性的7-跨膜结构域拓扑结构，并且它们的活化促进与多种细胞内伴侣蛋白的复合物形成，其形成启动不同信号传导网络的基础以及决定受体本身的命运。活性GPCR信号传导的终止和从质膜的去除都由受体本身及其相互作用伴侣的蛋白质翻译后修饰控制。磷酸化、酰化和泛素化是GPCR信号转导、亚细胞运输和整体表达中研究最多的翻译后修饰。新出现的证据表明，蛋白质S-亚硝基化，一氧化氮部分共价连接到指定的半胱氨酸巯基，GPCR和/或其相关效应物也参与受体信号传导和表达的微调。这种新认识的GPCR系统修饰模式增加了另一组控制，以更精确地调节由这一大组受体引起的许多细胞功能。
G protein-coupled receptors (GPCRs) are the most numerous and diverse type of cell surface receptors, accounting for about 1% of the entire human genome and relaying signals from a variety of extracellular stimuli that range from lipid and peptide growth factors to ions and sensory inputs. Activated GPCRs regulate a multitude of target cell functions, including intermediary metabolism, growth and differentiation, and migration and invasion. The GPCRs contain a characteristic 7-transmembrane domain topology and their activation promotes complex formation with a variety of intracellular partner proteins, which form basis for initiation of distinct signaling networks as well as dictate fate of the receptor itself. Both termination of active GPCR signaling and removal from the plasma membrane are controlled by protein post-translational modifications of the receptor itself and its interacting partners. Phosphorylation, acylation and ubiquitination are the most studied post-translational modifications involved in GPCR signal transduction, subcellular trafficking and overall expression. Emerging evidence demonstrates that protein S-nitrosylation, the covalent attachment of a nitric oxide moiety to specified cysteine thiol groups, of GPCRs and/or their associated effectors also participates in the fine-tuning of receptor signaling and expression. This newly appreciated mode of GPCR system modification adds another set of controls to more precisely regulate the many cellular functions elicited by this large group of receptors.
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影响因子：
4.8
作者：
Ahn, S;Maudsley, S;Daaka, Y
通讯作者：
Daaka, Y
影响因子：
4.8
作者：
Cao, S;Yao, J;Shah, V
通讯作者：
Shah, V
DOI：
10.1073/pnas.190276697
发表时间：
2000-09-26
影响因子：
11.1
作者：
DeFea, KA;Vaughn, ZD;Bunnett, NW
通讯作者：
Bunnett, NW
影响因子：
4.8
作者：
Carman, CV;Lisanti, MP;Benovic, JL
通讯作者：
Benovic, JL
影响因子：
4.8
作者：
Boo, YC;Sorescu, G;Jo, HJ
通讯作者：
Jo, HJ