t(9;11) (p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia
t(9;11) (p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia
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DOI：
10.1016/j.leukres.2004.09.002
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发表时间：
2005-04-01
影响因子：
2.7
通讯作者：
Panarello, C
中科院分区：
文献类型：
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作者：
Morerio, C;Acquila, M;Panarello, C
罕见的t(9;11)（p22;p15）易位与未成熟的成人急性髓性白血病（AML）有关。我们报道了一种新型的NUP98和LEDGF基因融合在儿童AML中，具有M2-M3法国-美国-英国（FAB）亚型之间的中间特征，表现出相同的染色体重排。荧光原位杂交（FISH）和逆转录- pcr （RT-PCR）研究鉴定了NUP98外显子8与LEDGF外显子4在框架内融合的嵌合转录产物。(c) 2004 Elsevier Ltd.版权所有。
The rare t(9;11)(p22;p15) translocation is associated with adult acute myeloid leukemia (AML) with immature forms. We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement. Fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR) studies identified the chimeric transcript product of in-frame fusion of NUP98 exon 8 to LEDGF exon 4. (c) 2004 Elsevier Ltd. All rights reserved.