Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc
Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc
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DOI：
10.1021/jo049359m
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发表时间：
2004-08-20
影响因子：
3.6
通讯作者：
March, S
中科院分区：
文献类型：
--
作者：
Alexakis, A;Polet, D;March, S
基于邻位取代的联苯酚和手性胺的亚磷酰胺配体在铜催化的二烷基锌试剂与各种Michael受体的共轭加成中诱导高的对映选择性（ee高达99%）。特别是，最好的报告ee的获得无环硝基烯烃。
Phosphoramidite ligands, based on ortho-substituted biphenols and a chiral amine, induce high enantioselectivities (ee's up to 99%) in the copper-catalyzed conjugate addition of dialkylzinc reagents to a variety of Michael acceptors. Particularly, the best reported ee's were obtained for acyclic nitroolefins.