Fecal Calprotectin for Evaluating Postoperative Recurrence of Crohn's Disease: A Meta-analysis of Prospective Studies
Fecal Calprotectin for Evaluating Postoperative Recurrence of Crohn's Disease: A Meta-analysis of Prospective Studies
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DOI：
10.1097/mib.0000000000000262
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发表时间：
2015-02-01
影响因子：
4.9
通讯作者：
Chen, Min-hu
中科院分区：
文献类型：
--
作者：
Qiu, Yun;Mao, Ren;Chen, Min-hu
背景：粪便钙卫蛋白（FC）水平已被广泛报道与克罗恩病（CD）的临床和内镜活动相关;然而，FC水平在术后环境中的效用仍有待确定。使用荟萃分析，我们的目的是评估的效用FC作为一个非侵入性的复发标志物的患者CD谁经历了以前的手术surgery.Methods：电子搜索使用相关的CD和FC的关键字进行了多个电子资源从1966年至2014年3月。提取的数据进行汇总使用分层汇总受试者工作曲线model.Results：10篇文章符合纳入标准，并为每个研究的方法学质量进行了详细的确定。10项研究提供了613例术后CD患者的FC水平。评估可疑内镜复发的合并敏感性和特异性值分别为0.82（95%置信区间（CI），0.73-0.89，8项研究，n = 391）和0.61（95% CI，0.51-0.71）。总体阳性和阴性似然比分别为2.11（95% CI，1.68-2.66）和0.29（95% CI，0.197-0.44）。评估临床复发的合并灵敏度和特异性值分别为0.59（95%CI，0.47-0.71; 3项研究，n = 183）和0.88（95%CI，0.80-0.93）。总的阳性和阴性似然比分别为5.10和0.47.Conclusions：作为一个简单的和非侵入性的指标，FC是有用的CD患者术后复发的评估。
Background:Fecal calprotectin (FC) levels have been extensively reported to correlate with clinical and endoscopic activities in Crohn's disease (CD); however, the utility of FC levels in the postoperative setting remains to be determined. Using meta-analysis, we aimed to evaluate the utility of FC as a noninvasive marker of recurrence in patients with CD who had undergone previous surgical resection.Methods:An electronic search using keywords related to CD and FC was performed in multiple electronic resources from 1966 to March 2014. The extracted data were pooled using a hierarchical summary receiver operating curve model.Results:Ten articles met the inclusion criteria, and methodological quality was determined in detail for each study. The 10 studies presented FC levels in 613 postoperative CD patients. The pooled sensitivity and specificity values for assessing suspected endoscopic recurrence were 0.82 (95% confidence interval (CI), 0.73-0.89, 8 studies, n = 391) and 0.61 (95% CI, 0.51-0.71), respectively. The overall positive and negative likelihood ratios were 2.11 (95% CI, 1.68-2.66) and 0.29 (95% CI, 0.197-0.44), respectively. The pooled sensitivity and specificity values for evaluating clinical relapse were 0.59 (95% CI, 0.47-0.71; 3 studies, n = 183) and 0.88 (95% CI, 0.80-0.93), respectively. The overall positive and negative likelihood ratios were 5.10 and 0.47, respectively.Conclusions:As a simple and noninvasive marker, FC is useful in evaluating recurrence of postoperative patients with CD.