PPAR-gamma Fun(gi) With Prostaglandin.
PPAR-gamma Fun(gi) With Prostaglandin.
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DOI：
10.1177/1550762919899641
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发表时间：
2020
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在我们最近的出版物中，我们首次表明真菌病原体新型隐球菌能够通过产生模拟宿主中发现的类花生酸来操纵宿主细胞。使用互补的隐球菌感染的体内斑马鱼和体外巨噬细胞培养模型，我们发现这些类花生酸通过激活宿主受体PPAR-gamma来操纵宿主先天免疫细胞，PPAR-gamma是巨噬细胞炎症表型的重要调节因子。我们最初将PGE 2鉴定为负责这种效应的类二十烷酸种类;然而，我们后来发现PGE 2的衍生物-15-酮-PGE 2-是最终负责的，并且这种类二十烷酸充当了对PPAR-gamma的部分激动剂。在这篇评论中，我们将讨论我们最初出版物中的一些概念和结论，并扩展其含义和未来方向。
In our recent publication, we show for the first time that the fungal pathogen Cryptococcus neoformans is able to manipulate host cells by producing eicosanoids that mimic those found in the host. Using complementary in vivo zebrafish and in vitro macrophage cell culture models of Cryptococcus infection, we found that these eicosanoids manipulate host innate immune cells by activating the host receptor PPAR-gamma which is an important regulator of macrophage inflammatory phenotypes. We initially identified PGE2 as the eicosanoid species responsible for this effect; however, we later found that a derivative of PGE2—15-keto-PGE2—was ultimately responsible and that this eicosanoid acted as a partial agonist to PPAR-gamma. In this commentary, we will discuss some of the concepts and conclusions in our original publication and expand on their implications and future directions.