The correlation between adiposity and adiponectin tumor necrosis factor α, interleukin-6 and high sensitivity C-reactive protein levels.: Is adipocyte size asssociated with inflammation in adults?
The correlation between adiposity and adiponectin tumor necrosis factor α, interleukin-6 and high sensitivity C-reactive protein levels.: Is adipocyte size asssociated with inflammation in adults?
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DOI：
10.1007/bf03347427
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发表时间：
2007-03-01
影响因子：
5.4
通讯作者：
Arikan, S.
中科院分区：
文献类型：
--
作者：
Bahceci, M.;Gokalp, D.;Arikan, S.
目的：肥厚性肥胖与肥胖代谢并发症相关。我们评估了脂肪细胞体积及其与肿瘤坏死因子ct（TNF-ct）、白细胞介素6（IL-6）、脂联素和高敏C反应蛋白（hs-CRP）水平的关系。研究对象和方法：患者被分为4组：瘦型健康对照组[体重指数（BMI）：24.2 +/- 1.4 kg/m2]、非糖尿病肥胖患者组（30.2 +/- 2.9）、肥胖（30.1 +/- 3.2）和非肥胖（22.2 +/- 11.5）2型糖尿病患者。TNF-α，术前测定hs-CRP、脂联素、IL-6水平，术中取皮下脂肪标本。半薄切片用甲苯胺蓝染色，并通过光学显微镜进行评价。通过Goldrick公式计算脂肪体积。结果：肥胖糖尿病患者的平均脂肪细胞体积高于其他组（p
Objective: Hypertrophic obesity correlates with metabolic complications of obesity. We evaluated adipocyte volume and its relationship with tumor necrosis factor ct (TNF-ct), interleukin-6 (IL-6), adiponectin and high sensitivity C-reactive protein (hs-CRP) levels. Subjects and methods: Patients were divided into 4 groups; lean healthy controls [body mass index (BMI): 24.2 +/- 1.4 kg/m(2)], non-diabetic obese patients (30.2 +/- 2.9), obese (30.1 +/- 3.2) and non-obese (22.2 +/- 11.5) Type 2 diabetic patients. TNF-a., hs-CRP, adiponectin and IL-6 levels were measured preoperatively and sc fat specimens were obtained during operation. Semi-thin sections were stained with toluidine-blue and evaluated by light microscopy. Fat volumes were calculated by Goldrick's formulation. Results: Mean adipocyte volumes were higher in obese diabetic patients than in other groups (p