The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3
The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3
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DOI：
10.1006/geno.1996.4500
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发表时间：
1997-01-15
期刊：
影响因子：
4.4
通讯作者：
Burn, TC
中科院分区：
文献类型：
--
作者：
Connors, TD;VanRaay, TJ;Burn, TC
在原核和真核细胞中，三磷酸腺苷结合盒(ABC)转运体或交通ATPase是一大类蛋白质家族，负责多种底物跨细胞膜的转运。我们描述了一种人类ABC蛋白，其区域与最近描述的小鼠ABC1和ABC2转运蛋白具有很强的同源性。这种新蛋白的基因，人ABC3，定位在染色体16p13.3上的多囊肾病1型(PKD1)基因附近。与其他组织相比，ABC3基因在肺中的表达水平最高。(C)1997年学术出版社
The ATP binding cassette (ABC) transporters, or traffic ATPases, constitute a large family of proteins responsible for the transport of a wide variety of substrates across cell membranes in both prokaryotic and eukaryotic cells. We describe a human ABC protein with regions of strong homology to the recently described murine ABC1 and ABC2 transporters. The gene for this novel protein, human ABC3, maps near the polycystic kidney disease type 1 (PKD1) gene on chromosome 16p13.3. The ABC3 gene is expressed at highest levels in lung compared to other tissues. (C) 1997 Academic Press