Effect of calcium on iron absorption in women with marginal iron status
Effect of calcium on iron absorption in women with marginal iron status
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DOI：
10.1017/s0007114509992418
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发表时间：
2010-03-14
影响因子：
3.6
通讯作者：
Cockell, Kevin A.
中科院分区：
文献类型：
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作者：
Benkhedda, Karima;L'Abbe, Mary R.;Cockell, Kevin A.
我们测量非血红素铁吸收和不添加钙在短期喂养的研究中，在13名妇女的边缘铁状态，通过使用双稳定同位素技术。补充500 mg Ca（以碳酸钙形式）显著（P=0.0009）降低了单餐的Fe吸收，从10.2%（范围2.2-40.6）降至4.8%（范围0.7-18-9）。不存在（-0.677 P=0.010）和存在（-0.58）时呈显着负相关。P=0.037）的钙，分别发现之间的铁吸收和铁储存测定血清铁蛋白（SF）。广泛的变化，在铁的吸收观察个人之间的存在和不存在的钙，尽管预选的参与者在一个相对狭窄的范围内的铁商店（SF浓度）。根据组平均SF校正铁吸收数据对降低铁吸收的个体间变异性没有帮助。看来，选择一个研究组与一个狭窄的初始范围内的铁商店不一定会减少个体间的变异性，铁生物利用度测量。这些结果支持了体内铁储存的假设。虽然这些因素都是影响膳食铁吸收的重要因素，但在低铁储备的受试者中，在相同的膳食摄入条件下，它们并不是决定铁吸收的主要因素。
We measured non-haem Fe absorption with and without added Ca in a short-term feeding study, in thirteen women with marginal Fe status, by the use of a double stable isotope technique. Supplementing 500 mg Ca as calcium carbonate significantly (P=0.0009) reduced Fe absorption from a single meal from 10.2 % (range 2.2-40.6) to 4.8 % (range 0.7-18-9). A significant inverse correlation in the absence (-0.677 P=0.010) and presence (-0.58. P=0.037) of Ca, respectively, was found between Fe absorption and Fe stores measured by serum ferritin (SF). Wide variation in Fe absorption was observed between individuals in the absence and in the presence of Ca, despite pre-selection of participants within a relatively narrow range of iron stores (SF concentrations). Correction of Fe absorption data based on group mean SF was not found to be useful in reducing the inter-individual variability in iron absorption. It appears that selecting a study group with a narrow initial range of Fe stores does not necessarily reduce the inter-individual variability in Fe bioavailability measurements. These results support the hypothesis that body Fe stores. although all important determinant of dietary Fe absorption, are riot the main factor that determines Fe absorption under conditions of identical dietary intake in subjects with low Fe stores.