The Intriguing Role of Neuropeptides at the Ocular Surface
The Intriguing Role of Neuropeptides at the Ocular Surface
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DOI：
10.1016/j.jtos.2016.10.003
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发表时间：
2017-01-01
期刊：
影响因子：
6.4
通讯作者：
Bonini, Stefano
中科院分区：
文献类型：
--
作者：
Sabatino, Francesco;Di Zazzo, Antonio;Bonini, Stefano
近几十年来，神经肽在生理和病理中的作用已被阐明。各种神经肽在眼睛表面表达，在那里它们促进免疫和神经系统之间的相互作用。它们积极调节营养和免疫功能，并协调神经炎症。本文综述了神经肽SP、VIP、CGRP和NPY在眼表的表达，重点阐述了它们在趋向性和免疫中的作用，并综述了它们在眼免疫豁免、感染、干眼和过敏性眼病中的作用。
In recent decades, the role of neuropeptides in physiology and pathology has been elucidated. Various neuropeptides are expressed at the ocular surface, where they facilitate the crosstalk between immune and nervous systems. They actively regulate trophic and immune functions and orchestrate neuroinflammation. The purpose of this manuscript is to review the expression of the neuropeptides SP, VIP, CGRP, and NPY at the ocular surface, focusing on their role in tropism and immunity, and to summarize their functions in ocular immune privilege, infection, dry eye, and allergic eye disease.