Serum Levels of Androgen-Associated Hormones Are Correlated with Curative Effect in Androgenic Alopecia in Young Men.
Serum Levels of Androgen-Associated Hormones Are Correlated with Curative Effect in Androgenic Alopecia in Young Men.
复制标题
血清雄激素相关激素水平与青年男性雄激素性脱发疗效相关
DOI：
10.12659/msm.913116
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发表时间：
2018-10-30
期刊：
影响因子：
--
通讯作者：
Lv Z
中科院分区：
文献类型：
--
作者：
Zhang Y;Xu J;Jing J;Wu X;Lv Z
背景雄激素性脱发(AGA)是男性最常见的脱发类型。然而，其发病机制尚不完全清楚，治疗方法也很有限。这项回顾性研究调查了年轻男性AGA患者雄激素相关激素水平与雄激素性脱发疗效的关系。材料/方法采用化学发光免疫分析法检测178例年轻男性AGA患者治疗前、非那雄胺治疗后1周和2周的血清雄激素及上游调节激素水平，并与61例正常对照组进行比较。结果口服非那雄胺治疗前，AGA患者血清游离睾酮(FT)和双氢睾酮(DHT)水平明显高于正常对照组。两组血清性激素结合球蛋白(SHBG)、黄体生成素(LH)、卵泡刺激素(FSH)水平相似。脱发严重程度不同的AGA患者之间血清雄激素水平，包括DHT和FT水平没有显著差异(p>；0.05)。经非那雄胺治疗后，DHT水平显著下降(p<；0.05)。55例患者治疗后血清促黄体生成素或促黄体生成素水平也升高(p<；0.05)。治疗后SHGB水平无明显变化(p>；0.05)。接受非那雄胺治疗的患者血清FT和DHT水平低于治疗前，严重程度分级改善的有效率高于治疗前(p<；0.05)。与治疗后无变化的患者相比，促黄体生成素或促黄体生成素水平升高的患者治愈率较低(p<；0.05)。结论证实雄激素下丘脑-垂体-性腺轴在AGA发病机制中的作用及口服抗雄激素治疗对AGA的治疗效果。
Background Androgenic alopecia (AGA) is the most common type of hair loss in men. However, the pathogenesis is not yet fully understood and therapeutic approaches are limited. This retrospective study investigated the association between levels of androgen-associated hormones and curative effect in androgenic alopecia in young male AGA patients. Material/Methods By using chemiluminescence immunoassay, serum levels of androgens and upstream regulated hormones were measured in 178 young male patients with AGA and in 61 normal controls before therapy, 1 and 2 weeks after administration of finasteride. Results Before oral finasteride therapy, we found significantly higher levels of serum free testosterone (FT) and dihydrotestosterone (DHT) in AGA patients than in normal controls. The levels of serum sex hormone-binding globulin (SHBG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were similar in the 2 groups. There were no significant differences in serum androgen levels, including DHT and FT, among AGA patients with different grades of hair loss severity (p>0.05). After finasteride therapy, the levels of DHT decreased significantly (p<0.05). Increased serum levels of LSH or LH were also observed in 55 patients after therapy (p<0.05). The levels of SHGB did not change significantly after therapy (p>0.05). Patients with lower levels of serum FT and DHT than before who accepted finasteride therapy had a higher ratio of curative effect manifested by improved severity grade (p<0.05). Patients with higher levels of LSH or LH had a lower curative rate compared to those without change after therapy (p<0.05). Conclusions We confirmed the role of the androgens hypothalamus-hypophysis-sexual gland axis in the pathogenesis of AGA and the treatment effect of oral anti-androgen therapy in young male Chinese patients.