Expanding Spectrum of Encephalitis With NMDA Receptor Antibodies in Young Children
Expanding Spectrum of Encephalitis With NMDA Receptor Antibodies in Young Children
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DOI：
10.1177/0883073809343319
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发表时间：
2010-06-01
影响因子：
1.9
通讯作者：
Tardieu, Marc
中科院分区：
文献类型：
--
作者：
Lebas, Axel;Husson, Beatrice;Tardieu, Marc
本文报告2例伴有n -甲基- d -天冬氨酸（NMDA）受体抗体的亚急性脑炎。其中一名患者患有与神经母细胞瘤相关的副肿瘤综合征，而另一名患者没有原发肿瘤。这种疾病最初被描述为卵巢畸胎瘤的年轻女性的副肿瘤综合征。这两名儿童的临床特征与老年患者的典型症状相似：精神运动恶化、运动障碍和癫痫发作。其中一个报告的病例是第一例已知的副肿瘤脑炎与NMDA抗体在儿童与神经母细胞瘤。这里描述的两个病例都比以前报告的任何病例年轻。与最近发表的系列报告一致，该报告表明，NMDA受体抗体脑炎的症状范围可能比以前认为的更广泛。
The authors report here 2 cases of subacute-onset encephalitis with N-methyl-D-aspartate (NMDA) receptor antibodies. One had a paraneoplastic syndrome associated with a neuroblastoma, whereas the other had no primary tumor. This disease was originally described as a paraneoplastic syndrome in young women with ovarian teratoma. The clinical features of both children resembled the typical symptoms reported for older patients with this disease: psychomotor deterioration, movement disorders, and seizures. One of the reported cases is the first known case of paraneoplastic encephalitis with NMDA antibodies in a child with neuroblastoma. Both cases described here were younger than any of the previously reported cases. Consistent with recently published series, this report suggests that the spectrum of symptoms of encephalitis with NMDA receptor antibodies is probably wider than previously thought.