Assisted exercise improves bone strength in very low birthweight infants by bone quantitative ultrasound
Assisted exercise improves bone strength in very low birthweight infants by bone quantitative ultrasound
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DOI：
10.1111/j.1440-1754.2010.01822.x
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发表时间：
2010-11-01
影响因子：
1.7
通讯作者：
Jao, Hsiao-Ching
中科院分区：
文献类型：
--
作者：
Chen, Hsiu-Lin;Lee, Chia-Ling;Jao, Hsiao-Ching
目的：探讨辅助运动是否能预防早产儿骨量减少的发生，对极低出生体重（VLBW）早产儿进行辅助运动。方法：16例出生体重低于1500 g的早产儿随机分为运动组（n = 8）和对照组（n = 8）。辅助运动包括由受过训练的护士进行上肢和下肢的完全伸展和屈曲运动范围，每周5天，共4周。骨强度测定胫骨超声定量测量速度的声音，每2 weeks在studyperiod.Results：性别，出生体重，孕龄之间的运动和对照组没有显着差异。在出生后第6周和第8周，运动组的胫骨声速下降有统计学意义。在研究期间，有没有统计学意义上的差异，血液生化数据，包括钙，磷，镁，碱性磷酸酶，骨钙素和骨保护素，两组之间，结论：这项研究表明，早期辅助运动可以提高极低出生体重儿的骨强度。骨代谢生化指标骨钙素和骨保护素不能作为早产儿骨量减少的早期诊断指标。
Aim:To evaluate whether assisted exercise could prevent the development of osteopenia of prematurity, we performed assisted exercise in the study group of very low birthweight (VLBW) premature infants.Methods:Sixteen premature infants with birthweight below 1500 g were enrolled in this study and randomly assigned into the exercise (n = 8) and control (n = 8) groups. Assisted exercise involved full extension and flexion range of motion of the upper and lower extremities by a trained nurse with a schedule of 5 days a week for a total of 4 weeks. Bone strength was determined by quantitative ultrasound measurement of tibial bone speed of sound every 2 weeks during the study period.Results:No difference in gender, birthweight, and gestation age between the exercise and control groups was noted. There was statistically significant less tibial bone speed of sound decrease in the exercise group on the sixth and eighth week of life. During the study period, there were no statistically significant differences in blood biochemistry data, including calcium, phosphorus, magnesium, alkaline phosphatase, osteocalcin and osteoprotegerin, between the two groups.Conclusions:This study revealed that early assisted exercise could improve bone strength in very low birthweight infants. The biochemical markers of bone metabolism, osteocalcin and osteoprotegerin, could not be the indicators for early diagnosis of osteopenia of prematurity.