DEVELOPMENT OF DIENCEPHALON IN RAT .3. ONTOGENY OF SPECIALIZED VENTRICULAR LININGS OF HYPOTHALAMIC THIRD VENTRICLE
DEVELOPMENT OF DIENCEPHALON IN RAT .3. ONTOGENY OF SPECIALIZED VENTRICULAR LININGS OF HYPOTHALAMIC THIRD VENTRICLE
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DOI：
10.1002/cne.901820513
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发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
BAYER, SA
中科院分区：
文献类型：
--
作者：
ALTMAN, J;BAYER, SA
在发育期间用3 H-胸苷标记的成熟大鼠和一系列紧密间隔的胚胎和婴儿大鼠中，用放射自显影法检查了下丘脑第三脑室专门衬里的发育。在成熟的大鼠，除了典型的室管膜壁，3个特化的衬里被区分：曲室管膜，层压上皮和tanycytic上皮。下丘脑前部和后部的大部分室壁由纤毛室管膜细胞组成，其中大部分是在出生前几天产生的，在邻近的下丘脑核团的神经发生停止后不久。邻近室旁核的头曲室管膜细胞与邻近的光滑室管膜细胞几乎同时产生。它的细胞来自同一生发区，显然产生大细胞神经垂体分泌系统的神经元。旋绕室管膜的结构分化在出生后开始，并在第2周开始时完成。层压上皮的室管膜细胞在出生后产生，形成平行室管膜下行的特化细胞的产生延伸到第3周。这些细胞似乎来自同一基质，早期产生的背内侧和腹内侧下丘脑核的神经元。它们的结构分化开始于第2周。粗细胞上皮细胞主要在出生后产生，主要在第1周。它们似乎起源于早期产生垂体结节乳头核和弓状核神经元的同一基质。这3种特化的脑室衬里显然与下丘脑内分泌的3种成分特别相关，它们与下丘脑共同起源于神经上皮部位。
The development of the specialized linings of the hypothalamic 3rd ventricle was examined autoradiographically in mature rats that were labeled with 3H-thymidine during the developmental period and in a closely spaced series of embryonic and infant rats. In mature rats, apart from the typical ependymal wall, 3 specialized linings were distinguished: the convoluted ependyma, the laminated epithelium and the tanycytic epithelium. The ventricular wall of most of the anterior hypothalamus and of the dorsal portion of the posterior hypothalamus is composed of ciliated ependymal cells, most of which are generated several days before birth, soon after the cessation of neurogenesis in the adjacent hypothalamic nuclei. The cells of the rostral convoluted ependyma adjacent to the paraventricular nucleus are produced at about the same time as the neighboring cells of the smooth ependyma. Its cells come from the same germinal region that apparently generates the neurons of the magnocellular neurohypophysial secretory system. The structural differentiation of the convoluted ependyma starts after birth and is completed by the beginning of the 2nd wk. Many of the ependymal cells of the laminated epithelium are produced postnatally and the production of the specialized cells that form a parallel subependymal row extends into the 3rd wk. These cells appear to arise from the same matrix that earlier generates the neurons of the dorsomedial and ventromedial hypothalamic nuclei. Their structural differentiation begins during the 2nd wk. The cells of the tanycytic epithelium are mostly produced postnatally, predominantly during the 1st wk. They appear to arise from the same matrix that generated earlier the neurons of the hypophysiotropic tuberomammillary and arcuate nuclei. These 3 specialized ventricular linings apparently are specifically related to the 3 components of the endocrine hypothalamus with which they shared neuroepithelial sites of origin.