Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults
Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults
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DOI：
10.1016/j.diabres.2015.01.012
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发表时间：
2015-03-01
影响因子：
5.1
通讯作者：
McDermott, Robyn
中科院分区：
文献类型：
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作者：
Hays, Russell;Esterman, Adrian;McDermott, Robyn
目的：探讨粪圆线虫感染与2型糖尿病（T2DM）发生的关系。方法：2013年对澳大利亚北部偏远社区259名成年原住民进行横断面调查。采用ELISA法检测血清是否感染粪球菌。主要结果为嗜酸性粒细胞计数、T2DM诊断、HbA1c、BMI、空腹血脂、Hb、血压。结果：92名参与者（36%）既往感染过粪球菌，131名参与者（51%）患有2型糖尿病。经年龄、甘油三酯、血压和BMI等因素校正后（校正OR = 0.39, 0.23-0.67, P = 0.001），既往粪球菌感染（ELISA滴度>= 0.3）的患者诊断为T2DM的可能性比未感染的患者低61%。解释：在这个粪球菌和2型糖尿病患病率都很高的偏远社区，粪球菌感染似乎与成年人患2型糖尿病的风险显著降低有关。在动物模型中已经确定了一种合理的免疫机制。如果得到证实，这一结果可能对预防人类2型糖尿病和相关代谢紊乱具有实际意义。这一发现应该通过对两种情况的风险都很高的过渡人群进行更大规模的纵向研究来进一步探索。经费：本研究不需要外部资金。2015爱思唯尔爱尔兰有限公司版权所有。
Objective: To explore the relationship between infection with Strongyloides stercoralis and the likelihood of having type 2 diabetes mellitus (T2DM).Methods: Cross-sectional survey of 259 Aboriginal adults living in a remote community in northern Australia during 2013. Prior infection with S. stercoralis was determined by ELISA testing on serum. Main outcomes were eosinophil count, T2DM diagnosis, HbA1c, BMI, fasting lipids, Hb, blood pressure.Findings: Ninety two participants (36%) had prior infection with S. stercoralis and 131 (51%) had T2DM. Those with previous S. stercoralis infection (ELISA titre >= 0.3) were 61% less likely to have a diagnosis of T2DM than those uninfected, adjusted for age, triglycerides, blood pressure and BMI using propensity score (adjusted OR = 0.39, 0.23-0.67, P = 0.001).Interpretation: In this remote community where prevalence of both S. stercoralis and T2DM is very high, infection with S. stercoralis appears to be associated with a significantly reduced risk of T2DM in adults. A plausible immunological mechanism has been identified in animal models. If confirmed, this result may have practical implications for the prevention of T2DM and associated metabolic disorders in humans. This finding should be explored further with larger longitudinal studies in transitional populations where the risk of both conditions is high. Funding: No external funding was required for this study. (C) 2015 Elsevier Ireland Ltd. All rights reserved.