Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation
Hydration Mechanism in Blood-Compatible Polymers Undergoing Phase Separation
复制标题
DOI：
10.1021/acs.langmuir.1c02672
复制
发表时间：
2022-01-07
期刊：
影响因子：
3.9
通讯作者：
Harada, Yoshihisa
中科院分区：
文献类型：
--
作者：
Murakami, Daiki;Yamazoe, Kosuke;Harada, Yoshihisa
涉及中间水的相互作用对于新型血液相容性材料的设计至关重要。在这里，我们使用原子力显微镜，石英晶体微天平测量，和软X射线发射光谱的组合，以调查血液相容性的聚（2-甲氧基乙基丙烯酸酯）和非血液相容性的聚（丙烯酸正丁酯）接枝在金基板上的水的局部氢键配置。我们发现，最初纳入水诱导聚合物依赖的相分离，促进进一步的水吸收。对于血液相容性聚合物，四面体配位的水与吸附在接枝聚合物表面的低密度区域中的C=O基团上的水共存，为中间水的形成提供支架。中间水的量由官能团的类型、局部聚合物构型和聚合物形态决定。因此，血液相容性由复杂的水/聚合物相互作用决定。
Interactions involving intermediate water are crucial for the design of novel blood-compatible materials. Herein, we use a combination of atomic force microscopy, quartz crystal microbalance measurements, and soft X-ray emission spectroscopy to investigate the local hydrogenbonded configuration of water on blood-compatible poly(2-methoxyethyl acrylate) and non-blood-compatible poly(n-butyl acrylate) grafted on a gold substrate. We find that the initially incorporated water induces polymer-dependent phase separation, facilitating further water uptake. For the blood-compatible polymer, tetrahedrally coordinated water coexists with water adsorbed on C=O groups in low-density regions of the grafted polymer surface, providing a scaffold for the formation of intermediate water. The amount of intermediate water is determined by the type of functional groups, local polymer configuration, and polymer morphology. Thus, blood compatibility is governed by the complex water/polymer interactions.