Pd/Phosphoramidite Thioether Complex-Catalyzed Asymmetric N-Allylic Alkylation of Hydrazones with Allylic Acetates
Pd/Phosphoramidite Thioether Complex-Catalyzed Asymmetric N-Allylic Alkylation of Hydrazones with Allylic Acetates
复制标题
Pd/亚磷酰胺硫醚络合物催化腙与乙酸烯丙酯的不对称 N-烯丙基烷基化
DOI：
10.1021/acs.orglett.8b01226
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Wen-Jing Xiao
中科院分区：
文献类型：
--
作者：
Bin Lu;Bin Feng;Hui Ye;Jia-Rong Chen;Wen-Jing Xiao
首次开发了一种通用高效的钯/亚磷酰胺硫醚络合物催化的不对称N-烯丙基肼与烯丙基乙酸酯的烷基化反应。该反应允许制备各种有价值的N-取代肼类化合物，通常具有良好的产率和良好的对映体选择性。对配体进行少量的结构修饰可以得到相反的对映异构体，从而可以在相同的催化体系下合成对映体发散的产物。
A general and efficient Pd/phosphoramidite thioether complex-catalyzed asymmetricN-allylic alkylation of hydrazones with allylic acetates has been developed for the first time. The reaction allows for the preparation of various valuableN-substituted hydrazones with generally good yields and excellent enantioselectivities. Minor structural modification of the ligand resulted in opposite enantiomers, enabling enantiodivergent synthesis of products by the same catalytic system.