Magnetic stimulation of motor cortex in children: Maturity of corticospinal pathway and problem of clinical application
Magnetic stimulation of motor cortex in children: Maturity of corticospinal pathway and problem of clinical application
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DOI：
10.1016/s0387-7604(96)00552-9
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发表时间：
1997-04-01
影响因子：
1.7
通讯作者：
Saito, K
中科院分区：
文献类型：
--
作者：
Nezu, A;Kimura, S;Saito, K
研究人员对 46 名 1 至 14 岁神经系统正常儿童的经颅磁刺激 (TMS) 肌电图反应的发育概况进行了研究，并与 10 名正常对照成年人的数据进行了比较。为了获得静息状态下第一背侧骨间肌的运动诱发电位 (MEP)，通过圆形线圈刺激运动皮层，刺激强度设置为高于诱发 MEP 阈值强度 10%。除2岁以下儿童外，所有儿童均获得了可重复的MEP，阈值强度和中枢运动传导时间（CMCT）随着成熟呈线性下降。 MEP 幅度在 9 岁时变化不大，但在 10 岁至成年期间趋于增加。 MEP 持续时间不受年龄影响，在研究的年龄范围内小于 16 毫秒。目前的 dba 表明，控制手部内在肌肉的皮质脊髓运动通路在电生理学上在 13 岁时已完全成熟。在 MEP 参数中，CMCT 和 MEP 持续时间可能有助于评估 2 岁及以上儿童皮质脊髓束的损伤情况。 (C) 1997 Elsevier Science B.V.
The developmental profile of the electromyographic responses to transcranial magnetic stimulation (TMS) was studied in 46 neurologically normal children aged from one to 14 years, compared with data in 10 normal control adults. To obtain motor evoked potentials (MEPs) from the first dorsal interosseous muscle in the resting state, the motor cortex was stimulated through a circular coil with the stimulus intensity set at 10% above the threshold intensity for eliciting MEPs. Reproducible MEPs were obtained in all but the children aged below 2 years, and the threshold intensity and central motor conduction time (CMCT) showed a linear decrease with maturation. The MEP amplitude changed little until 9 years of age, but it tended to increase between 10 years and adulthood. The MEP duration, which was not influenced by age, was less than 16 ms over the ages studied. The present dba suggest that maturity of the corticospinal motor pathway that controls the intrinsic hand muscles is electrophysiologically complete at 13 years of age. Among the parameters of MEPs, CMCT and MEP duration may be useful for evaluating impairment of the corticospinal tracts in children aged 2 years and older. (C) 1997 Elsevier Science B.V.