Photodamage attenuation effect by a tetraprenyltoluquinol chromane meroterpenoid isolated from Sargassum muticum
Photodamage attenuation effect by a tetraprenyltoluquinol chromane meroterpenoid isolated from Sargassum muticum
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DOI：
10.1016/j.jphotobiol.2015.03.026
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发表时间：
2015-07-01
影响因子：
5.4
通讯作者：
Rodriguez, J.
中科院分区：
文献类型：
--
作者：
Balboa, E. M.;Li, Y. -X.;Rodriguez, J.
首次从褐藻马尾藻甲醇提取物的二氯甲烷馏分中分离出具有色满部分的四异戊二烯基甲苯醌二萜类化合物，以 C3 处的差向异构混合物形式获得。该结构是通过包括核磁共振波谱和质谱在内的光谱方法确定的，并与报道的数据进行比较。该化合物对 UVA 光照射的细胞显示出光损伤减弱作用，对细胞内 ROS 生成具有与视黄酸 (9.1-20.6%) 相当的保护作用，并且对人真皮成纤维细胞没有毒性。 (C) 2015 Elsevier B.V. 保留所有权利。
A tetraprenyltoluquinol meroterpenoid with a chromane moiety, obtained as an epimeric mixture at C3, was isolated for the first time from the dichloromethane fraction of a methanolic extract from the brown alga Sargassum muticum. The structure has been established by means of spectral methods including NMR spectroscopy and MS and comparison with reported data. The compound showed photodamage attenuation on irradiated cells with UVA light, presented protection against intracellular ROS generation in a degree comparable to retinoic acid (9.1-20.6%) and did not display toxicity against human dermal fibroblast cells. (C) 2015 Elsevier B.V. All rights reserved.