Magnetic resonance fingerprinting for simultaneous renal T1 and T2*mapping in a single breath-hold
Magnetic resonance fingerprinting for simultaneous renal T1 and T2*mapping in a single breath-hold
复制标题
DOI：
10.1002/mrm.28160
复制
发表时间：
2020-01-03
影响因子：
3.3
通讯作者：
Zoellner, Frank G.
中科院分区：
文献类型：
--
作者：
Hermann, Ingo;Chacon-Caldera, Jorge;Zoellner, Frank G.
目的评价磁共振指纹法（MRF）在单次屏气中同时定量肾脏T1和T2* 的应用。方法在MRF回波平面成像的基础上，提出了肾脏MRF序列。在15.4秒内对每个切片和总共4个切片进行了35次测量。进行组匹配以在线定量T1和T2*。在体模和8名健康志愿者中以冠状方向采集图像。为了评估我们的方法，在肾脏中绘制感兴趣区域以计算T1和T2* 时间的平均值和标准差。通过多次重复MRF扫描计算精密度。对基线图像进行高斯滤波，以提高信噪比和匹配稳定性。结果在体模中使用MRF获得的T1和T2* 时间与参考测量和常规标测方法具有良好的一致性，T1的偏差小于5%，T2* 的偏差小于10%。体内基线图像无伪影，弛豫时间与传统方法和文献具有良好的一致性（偏差T1：7 +/-4%，T2*：6 +/- 3%）。结论在本可行性研究中，所提出的肾脏MRF序列在单次屏气中可实现准确的T1和T2* 定量。
Purpose To evaluate the use of magnetic resonance fingerprinting (MRF) for simultaneous quantification of T1 and T2* in a single breath-hold in the kidneys. Methods The proposed kidney MRF sequence was based on MRF echo-planar imaging. Thirty-five measurements per slice and overall 4 slices were measured in 15.4 seconds. Group matching was performed for in-line quantification of T1 and T2*. Images were acquired in a phantom and 8 healthy volunteers in coronal orientation. To evaluate our approach, region of interests were drawn in the kidneys to calculate mean values and standard deviations of the T1 and T2* times. Precision was calculated across multiple repeated MRF scans. Gaussian filtering is applied on baseline images to improve SNR and match stability. Results T1 and T2* times acquired with MRF in the phantom showed good agreement with reference measurements and conventional mapping methods with deviations of less than 5% for T1 and less than 10% for T2*. Baseline images in vivo were free of artifacts and relaxation times yielded good agreement with conventional methods and literature (deviation T1:7 +/- 4%, T2*:6 +/- 3%). Conclusions In this feasibility study, the proposed renal MRF sequence resulted in accurate T1 and T2* quantification in a single breath-hold.