Further studies on the antipyretic action of polymyxin B in pyrogen-induced fever.
Further studies on the antipyretic action of polymyxin B in pyrogen-induced fever.
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多粘菌素B对热原性发热的解热作用进一步研究。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
van Duin Ct
中科院分区：
文献类型：
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作者：
V. As;van Duin Ct
：对多粘菌素 B 的退热作用进行了研究，以确定该药物如何帮助兔子退烧。它涉及药物的作用：（1）对外源性热原（大肠杆菌脂多糖、合成双链核糖核酸、酵母核酸钠）和白细胞热原引起的发热的影响，（2）对体内和体外内源性热原释放的影响，以及（3）对体外白细胞和外源性热原的影响。结果表明，多粘菌素B在内毒素引起的发热中主要通过该阳离子大分子与阴离子内毒素分子的相互作用产生解热作用。此外，多粘菌素B可能抑制内源性热原合成和/或多形核白细胞的释放。
: A study of the antipyretic effect of polymyxin B was undertaken to determine how this agent reduces fever in rabbits. It involved the effects of the drug: (1) on fever induced by exogenous pyrogenes (E. coli lipopolysaccharide, synthetic double-stranded ribonucleic acid, sodium nucleinate from yeast) and leucocytic pyrogen, (2) on the release of endogenous pyrogen in vivo and in vitro, and (3) on leucocytic and exogenous pyrogens in vitro. The results indicate that polymyxin B produces an antipyretic effect in endotoxin-induced fever primarily by an interaction of this cationic macromolecule with the anionic endotoxin molecule. Further it is likely that polymyxin B inhibits endogenous pyrogen synthesis and/or release from polymorphonuclear leucocytes.