Cerebellar transcranial magnetic stimulation impairs verbal working memory
Cerebellar transcranial magnetic stimulation impairs verbal working memory
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DOI：
10.1002/ana.20604
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发表时间：
2005-10-01
影响因子：
11.2
通讯作者：
Shich, PB
中科院分区：
文献类型：
--
作者：
Desmond, JE;Chen, SHA;Shich, PB
先前的功能磁共振成像和患者研究表明小脑参与言语工作记忆。特别是，事件相关的功能磁共振成像在斯滕伯格任务的初始编码阶段显示出优异的小脑激活。本研究使用功能性磁共振成像引导的经颅磁刺激 (TMS) 来测试右上小脑（半球小叶 VI/Crus I）的破坏是否会损害言语工作记忆表现。在一半的试验中，在编码阶段的字母呈现后立即进行单脉冲 TMS。假 TMS 和运动控制任务被纳入测试一般分心和非记忆相关的运动效应。结果显示，TMS 对准确性没有影响，但在言语工作记忆和运动控制任务中，相对于非 TMS 试验，TMS 正确试验的反应时间 (RT) 显着增加。其他分析表明，言语工作记忆的 RT 增加明显大于运动任务，这表明对工作记忆的影响不是由手指反应的干扰引起的。假 TMS 不会影响 RT，这表明编码后点击的潜在干扰效应不会导致 RT 的增加。观察到的小脑破坏的影响与所提出的小脑参与言语工作记忆的结果一致。
Previous functional magnetic resonance imaging and patient studies indicate cerebellar participation in verbal working memory. In particular, event-related functional magnetic resonance imaging showed superior cerebellar activation during the initial encoding phase of the Sternberg task. This study used functional magnetic resonance imaging-guided transcranial magnetic stimulation (TMS) to test whether disruption of the right superior cerebellum (hemispheric lobule VI/Crus I) impairs verbal working memory performance. Single-pulse TMS was administered immediately after letter presentation during the encoding phase on half the trials. Sham TMS and a Motor Control task were included to test for general distraction and nonmemory-related motor effects. Results showed no effects of TMS on accuracy, but reaction times (RTs) on correct trials were significantly increased on TMS relative to non-TMS trials for the Verbal Working Memory and Motor Control tasks. Additional analyses showed that the increased RT was significantly greater for Verbal Working Memory than for the motor task, suggesting that the effect on working memory was not caused by interference with finger responses. Sham TMS did not affect RTs, indicating that the potentially distracting effects of the postencoding click did not contribute to the increase in RT. The observed effects from cerebellar disruption are consistent with proposed cerebrocerebellar involvement in verbal working memory.