Poor intestinal permeability in mildly stunted Nepali children:: associations with weaning practices and Giardia lamblia infection
Poor intestinal permeability in mildly stunted Nepali children:: associations with weaning practices and Giardia lamblia infection
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DOI：
10.1079/bjn2002599
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发表时间：
2002-08-01
影响因子：
3.6
通讯作者：
Tuladhar, NR
中科院分区：
文献类型：
--
作者：
Goto, R;Panter-Brick, C;Tuladhar, NR
冈比亚的研究使用乳果糖-甘露醇双糖肠道渗透性测试（乳果糖：甘露醇比例）作为研究粘膜损伤的非侵入性方法，表明食物吸收不良与早期生长迟缓显着相关。在这项横断面研究中，招募了210名0-60个月大的尼泊尔城市贫困儿童，测量身高或身长和体重，检查了167名肠道通透性，173名寄生虫感染。断奶和发病率数据收集了172照顾者。儿童轻度发育迟缓（平均年龄身高z评分-1.45）和体重不足（平均年龄体重z评分-1.62）。乳果糖：甘露醇比例（0.26）低于英国儿童（0.12），但与孟加拉同龄儿童（0.24）相似。两个阶段的断奶，开始补充喂养（6个月）和停止母乳喂养（23个月），显示有不同的影响。在目前母乳喂养的儿童中，补充时间与乳糖呈负相关（P
Studies in the Gambia, using the lactulose-mannitol dual-sugar intestinal permeability test (lactulose:mannitol ratio) as a non-invasive way of investigating mucosal damage, have shown that food malabsorption is significantly associated with early growth retardation. In this cross-sectional study, 210 poor urban Nepali children, 0-60 months old, were recruited and measured for height or length and weight, 167 were examined for intestinal permeability and 173 for parasite infection. Weaning and morbidity data were collected from 172 caretakers. Children were mildly stunted (mean height-for-age z-score -1.45) and underweight (mean weight-for-age z-score -1.62). The lactulose:mannitol ratio (0.26) was poorer than that of UK children (0.12), but similar to that found in Bengali children of the same age (0.24). Two stages of weaning, the onset supplementary feeding (6 months) and the cessation of breast-feeding (23 months), were shown to have differential impact. In children currently breast-feeding, the duration of supplementation was negatively related to lactose (P