Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica
Meiotic sex chromosome inactivation in the marsupial Monodelphis domestica
复制标题
DOI：
10.1002/dvg.20345
复制
发表时间：
2007-11-01
期刊：
影响因子：
1.5
通讯作者：
McCarrey, John R.
中科院分区：
文献类型：
--
作者：
Hornecker, Jacey L.;Samollow, Paul B.;McCarrey, John R.
在真生殖哺乳动物中，雄性精子发生过程中，X和Y染色体经历减数分裂性染色体失活（MSCI）。然而，受精后，父本（Xp）和母本（Xm）遗传的X染色体在雌性囊胚的内细胞团中都活跃，然后在每个细胞中随机发生一条X染色体的失活，导致成年雌性组织中X染色体活动的马赛克模式。相比之下，雌性有袋动物表现出非随机的X染色体活动模式，在所有体细胞组织中Xp都受到抑制。在这里，我们发现MSCI也发生在有袋动物的精子发生过程中，其方式与真动物相似，但比真动物更稳定。这些发现支持了以下观点，即MSCI可能为哺乳动物的早期剂量补偿机制提供了基础，该机制仅基于配子体事件，并且胚胎发生期间随机x染色体失活可能随后在真动物中进化。创世纪45:696 - 708,2007。(c) 2007年wiley-liss公司。
In eutherian mammals, the X and Y chromosomes undergo meiotic sex chromosome inactivation (MSCI) during spermatogenesis in males. However, following fertilization, both the paternally (Xp) and maternally (Xm) inherited X chromosomes are active in the inner cell mass of the female blastocyst, and then random inactivation of one X chromosome occurs in each cell, leading to a mosaic pattern of X-chromosome activity in adult female tissues. In contrast, marsupial females show a nonrandom pattern of X chromosome activity, with repression of the Xp in all somatic tissues. Here, we show that MSCI also occurs during spermatogenesis in marsupials in a manner similar to, but more stable than that in eutherians. These findings support the suggestion that MSCI may have provided the basis for an early dosage compensation mechanism in mammals based solely on gametogenic events, and that random X-chromosome inactivation during embryogenesis may have evolved subsequently in eutherian mammals. genesis 45:696-708,2007. (c) 2007Wiley-Liss,Inc.