LONG-TERM FOOD RESTRICTION DEPRESSES SERUM THYROID-HORMONE CONCENTRATIONS IN THE RAT
LONG-TERM FOOD RESTRICTION DEPRESSES SERUM THYROID-HORMONE CONCENTRATIONS IN THE RAT
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DOI：
10.1016/0047-6374(90)90030-j
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发表时间：
1990-03-31
影响因子：
5.3
通讯作者：
BERTRAND, HA
中科院分区：
文献类型：
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作者：
HERLIHY, JT;STACY, C;BERTRAND, HA
长期限制食物对啮齿类动物具有抗衰老作用。其调节衰老过程的机制尚不清楚，但内分泌系统的变化被认为是食物限制与衰老的耦合因素。在 6 个月大的雄性 Fischer 344 大鼠中检查了长期食物限制对甲状腺激素血清浓度的影响。在 4.5 个月的时间里，食物限制组的喂食量是随意组的 60%。食物限制不会改变 24 小时平均 T4 浓度，但将 24 小时平均 T3 浓度从 95 .+- 降低。 1 至 87 .+-. 3纳克/分升。 Ad Libitum 组的血清 T4 和 T3 浓度均表现出昼夜节律，每种激素的峰值出现在 1000 小时。尽管食物限制消除了两种甲状腺激素的 1000 小时峰值，但它仅消除了 T3 的昼夜变化。饮食引起的血清 T4 和 T3 变化与这些激素在限制食物的抗衰老作用中的作用一致。
Long-term food restriction exerts an anti-aging action in rodents. The mechanism underlying its modulation of aging processes is unknown but changes in endocrine systems have been postulated as couplers of food restriction to aging. The effects of long-term food restriction on the serum concentrations of thyroid hormones were examined in 6-month-old, male Fischer 344 rats. For 4.5 months a Food Restricted group was fed 60% of the amount consumed by an Ad Libitum group. Food restriction did not alter the 24-h mean T4 concentration but reduced the 24-h mean T3 concentration from 95 .+-. 1 to 87 .+-. 3 ng/dl. The Ad Libitum group exhibited diurnal rhythms in both serum T4 and T3 concentrations, with peak values for each hormone at 1000 h. Although food restriction eliminated the 1000 h peak for both thyroid hormones, it abolished the diurnal variation only for T3. The dietary-induced changes in serum T4 and T3 are consistent with a role for these hormones in the anti-aging action of food restriction.