Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists
Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists
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DOI：
10.1016/j.crohns.2010.05.011
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发表时间：
2010-10-01
影响因子：
8
通讯作者：
Allez, Matthieu
中科院分区：
文献类型：
--
作者：
Chowers, Yehuda;Sturm, Andreas;Allez, Matthieu
第一届ECCO关于炎症性肠病抗TNF治疗失败的发病机制研讨会的第二部分讨论了TNF α的生物学作用以及TNF α拮抗剂的作用和机制。其失败的机制，包括诱导TNF-独立的炎症通路和矛盾的炎症现象进行了讨论。(C)2010年欧洲克罗恩病和结肠炎组织。Elsevier B. V.出版，保留所有权利。
This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNF alpha and the effects and mechanisms of action of TNF alpha antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed. (C) 2010 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.