Acyclovir prophylaxis in late pregnancy prevents recurrent genital herpes and viral shedding
Acyclovir prophylaxis in late pregnancy prevents recurrent genital herpes and viral shedding
复制标题
DOI：
10.1016/s0301-2115(00)00406-1
复制
发表时间：
2001-05-01
期刊：
影响因子：
--
通讯作者：
Oury, JF
中科院分区：
文献类型：
--
作者：
Braig, S;Luton, D;Oury, JF
新生儿疱疹大约每15,000名新生儿中就有1名感染，合并脑炎的播散性疾病的预后很差。我们调查了妊娠晚期预防阿昔洛韦是否有效地降低了病毒脱落的风险。因此，母婴传播的风险。进行了一项前瞻性研究。将孕期至少发生一次生殖器疱疹的孕妇随机分为两组：1组(n=167)孕期至足月口服阿昔洛韦，2组(n=121)不给予任何治疗。第3组(n=201)包括有生殖器疱疹病史的未给予预防措施的妇女。但在怀孕期间没有活跃的发作。剖宫产率第1组为8.3%，第3组为16.54%，第3组为9.9%(P<0.05)。
Neonatal herpes affects about 1 in 15,000 newborns and the prognosis for disseminated disease with encephalitis is poor. We investigated whether acyclovir prophylaxis in late pregnancy effectively reduces the risk of viral shedding and. hence, of mother-to-child transmission at delivery.A prospective study was conducted. Pregnant women who had at least one episode of genital herpes during pregnancy were randomly assigned to two groups: group 1 (n=167) received oral acyclovir from 36 weeks of gestation to term, group 2 (n=121) received no treatment. Group 3 (n=201) comprised women not given prophylaxis who had a history of genital herpes. but no active episodes during pregnancy. No specific instruction were set up for obstetrical management except For cesarean section in case of a suspected herpes lesion at the time of labor.The rate of Cesarean section was 8.3% in group 1, 16.54 in group 3, and 9.9% in group 3 (p