Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice, but Rb(6.15)-carrying tumors prefer Igk-Myc inversions over translocations.
Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice, but Rb(6.15)-carrying tumors prefer Igk-Myc inversions over translocations.
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Myc、Igh 和 Igk 在罗伯逊融合染色体上的位置对于 Myc 易位和小鼠浆细胞瘤的发展无关紧要，但携带 Rb(6.15) 的肿瘤更喜欢 Igk-Myc 倒位而不是易位。
DOI：
10.1002/gcc.20149
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Janz,Siegfried
中科院分区：
文献类型：
--
作者：
Silva,Santiago;Wiener,Francis;Klein,George;Janz,Siegfried
The location of theMycand immunoglobulin (Ig) loci on metacentric Robertsonian (Rb) fusion chromosomes may affect the development of mouse plasmacytomas (Pcts) by changing the probability with which chromosomalMyc–Igtranslocations occur. To test this hypothesis, we induced Pcts in BALB/c (C) mice that carried Rb(4.12) and/or Rb(6.15) chromosomes. The Rb mice developed Pcts (n= 198) with similar onset and incidence to that in the inbred C mice. Karyotyping of 70 Rb–carrying Pcts demonstrated that in these tumors, just as in their counterparts in inbred C mice, theIghheavy‐chain locus was translocated withMycmore often than was theIgklight‐chain locus. Pcts harboringIghorIgkon normal and Rb chromosomes showed no bias toward either in generatingMyctranslocations. These findings indicated that the location ofMyc,Igh, andIgkon normal or Rb chromosomes is inconsequential forMyctranslocation and Pct development. In contrast, in Rb(6.15) mice, in which chromosomal inversions competed with chromosomal translocations forIgk–Mycjuxtapositions, the former occurred more frequently than the latter in the resulting Pcts. This suggested that spatial proximity ofIgkandMycon the same chromosome facilitates the rearrangement of these loci.Myctranslocation–dependent mouse Pct may provide a good model system for furthering our understanding of the relationship of higher‐order genome organization in the interphase nucleus, origin of chromosomal translocations, and development of cancer. Published 2005 Wiley‐Liss, Inc.
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作者：
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DOI：
--
发表时间：
1987
期刊：
影响因子：
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作者：
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通讯作者：
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