Independence of salt intake from the hormones regulating calcium homeostasis.
Independence of salt intake from the hormones regulating calcium homeostasis.
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盐摄入量与调节钙稳态的激素无关。
DOI：
10.1152/ajpregu.1993.264.3.r500
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Pilchak,DM
中科院分区：
文献类型：
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作者：
Tordoff,MG;Hughes,RL;Pilchak,DM
剥夺膳食钙的大鼠增加NaCl溶液的自愿摄入。我们调查了控制钙稳态的主要激素是否是盐摄入量增加的原因。通过甲状腺切除术和/或甲状旁腺切除术去除内源性降钙素和甲状旁腺激素对NaCl摄入量没有影响。手术受损的大鼠和他们的完整的控制喝类似数量的NaCl，以应对饮食钙含量的操纵。尽管正常的氯化钠摄入量，大鼠甲状旁腺切除术有低血浆钙浓度和强烈的食欲50 mM氯化钙溶液。慢性甲状旁腺激素输注到大鼠甲状腺甲状旁腺切除术减少氯化钠的摄入量。喂食美国营养研究所（AIN）-76 A为基础的维生素D缺乏饮食的完整大鼠略微增加了NaCl摄入量，并显示出对CaCl 2的强烈食欲，但其他大鼠通过向维生素D缺乏饮食中添加钙、磷和乳糖来维持正常的钙含量，具有正常的NaCl和CaCl 2摄入量。慢性输注1，25-二羟维生素D3到完整的大鼠没有影响氯化钠的摄入量。总之，这些结果表明，增加氯化钠摄入量所产生的钙剥夺是不介导的钙，降钙素，甲状旁腺激素，或1，25-二羟维生素D3的循环水平的变化。此外，主要的钙调节激素不参与控制大鼠的“自发”NaCl摄入。
Rats deprived of dietary calcium increase voluntary intake of NaCl solutions. We investigated whether the major hormones controlling calcium homeostasis are responsible for this increase in salt intake. Removing endogenous sources of calcitonin and parathyroid hormone by thyroidectomy and/or parathyroidectomy had no effect on NaCl intake. The surgically compromised rats and their intact controls drank similar amounts of NaCl in response to manipulations of diet calcium content. Despite normal NaCl intakes, rats with parathyroidectomy had low plasma calcium concentrations and a strong appetite for 50 mM CaCl2 solution. Chronic infusion of parathyroid hormone into rats with thyroparathyroidectomy decreased NaCl intake. Intact rats fed an American Institute of Nutrition (AIN)-76A-based vitamin D-deficient diet increased NaCl intake slightly and showed a strong appetite for CaCl2, but other rats maintained normocalcemic by the addition of calcium, phosphorus, and lactose to the vitamin D-deficient diet had normal NaCl and CaCl2 intakes. Chronic infusions of 1,25-dihydroxyvitamin D3 into intact rats had no effect on NaCl intake. Taken together, these results indicate that the increase in NaCl intake produced by calcium deprivation is not mediated by changes in circulating levels of calcium, calcitonin, parathyroid hormone, or 1,25-dihydroxyvitamin D3. Furthermore, the major calcium-regulating hormones are not involved in the control of "spontaneous" NaCl intake in the rat.