A review of studies with chlorhexidine applied directly to the umbilical cord.
A review of studies with chlorhexidine applied directly to the umbilical cord.
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DOI：
10.1055/s-0032-1329695
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发表时间：
2013-09
影响因子：
2
通讯作者：
Saleem S
中科院分区：
文献类型：
--
作者：
Goldenberg RL;McClure EM;Saleem S
在发展中国家，由脐炎引起的感染相关新生儿死亡率是一个重要的公共卫生问题。三个整群随机试验评估了这种干预措施与其他类型的脐带护理相比，对脐带炎和新生儿死亡率的影响。这3项研究中的每一项都显示，使用4%的洗必泰可以显著降低脐炎、新生儿死亡率或两者兼而有之。然而，最优的给药计划仍然不确定。虽然还需要进一步的研究来澄清这个问题，但从这3项研究中可以清楚地看到，分娩后至少一次将4%的洗必泰应用于脐带残端，可以减少脐炎和新生儿死亡率，特别是在早产儿中。这种干预是安全、廉价的，只需要最少的培训和技能，应该强烈考虑在任何家庭分娩的地方采用。
Infection-related neonatal mortality due to omphalitis in developing country home births is an important public health problem. Three cluster randomized trials of 4% chlorhexidine applied to the umbilical cord stump from 1 to multiple times in the days following a home birth have evaluated this intervention compared to other types of cord care on the development of omphalitis and neonatal mortality. Each of the 3 studies showed significant reductions in either omphalitis, neonatal mortality, or both with the 4% chlorhexidine. However, the optimal dosing schedule remains uncertain. While further studies are needed to clarify this issue, from the 3 studies it is now clear that with a minimum of one application of 4% chlorhexidine to the umbilical cord stump following delivery, the incidence of omphalitis and neonatal mortality can be reduced, especially in preterm newborns. This intervention, which is safe, inexpensive and requires minimal training and skill, should strongly be considered for adoption wherever home births occur.
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影响因子：
--
作者：
Taha, TE;Biggar, RJ;Miotti, PG
通讯作者：
Miotti, PG
影响因子：
168.9
作者：
Cutland, Clare L.;Madhi, Shabir A.;Schrag, Stephanie J.
通讯作者：
Schrag, Stephanie J.
影响因子：
15.8
作者：
Oestergaard MZ;Inoue M;Yoshida S;Mahanani WR;Gore FM;Cousens S;Lawn JE;Mathers CD;United Nations Inter-Agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group
通讯作者：
United Nations Inter-Agency Group for Child Mortality Estimation and the Child Health Epidemiology Reference Group
影响因子：
7.2
作者：
Saleem S;Rouse DJ;McClure EM;Zaidi A;Reza T;Yahya Y;Memon IA;Khan NH;Memon G;Soomro N;Pasha O;Wright LL;Moore J;Goldenberg RL
通讯作者：
Goldenberg RL
影响因子：
168.9
作者：
Soofi, Sajid;Cousens, Simon;Bhutta, Zulfiqar A.
通讯作者：
Bhutta, Zulfiqar A.