The origin of the Mullerian duct in chick and mouse
The origin of the Mullerian duct in chick and mouse
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DOI：
10.1016/j.ydbio.2006.09.046
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发表时间：
2007-02-15
影响因子：
2.7
通讯作者：
Lovell-Badge, Robin
中科院分区：
文献类型：
--
作者：
Guioli, Silvana;Sekido, Ryohei;Lovell-Badge, Robin
在脊椎动物中，雌性生殖道来自一对被称为米勒管的管状结构，它由三个元素组成：管状上皮管、围绕管子的间充质细胞，以及最外面的体腔上皮细胞。自1830年约翰尼斯·彼得·穆勒首次描述以来，构成穆勒管的细胞的起源一直存在争议。我们报道了在鸡和小鼠胚胎中进行的谱系追踪实验的结果，目的是提供米勒管形成的动力学信息。我们发现所有的苗勒管成分都来自两个物种的体腔上皮。我们的数据支持一种米勒上皮管模型，该模型来源于中肾前端的上皮原基，然后通过参与细胞快速增殖的过程从上皮分离出来，并自动延伸到尾部。这个管子周围是来自体腔上皮局部分层的间充质细胞。我们排除了任何来自Wolffian管的细胞的显著流入，也排除了体腔上皮沿中肾内陷形成管状的观点。我们的数据提供了与女性生殖道正常和异常发育相关的小管发生的潜在机制的线索。(C)2006 Elsevier Inc.保留所有权利。
In vertebrates the female reproductive tracts derive from a pair of tubular structures called Mullerian ducts, which are composed of three elements: a canalised epithelial tube, mesenchymal cells surrounding the tube and, most externally, coelomic epithelial cells. Since the first description by Johannes Peter Muller in 1830, the origin of the cells making up the Mullerian duct has remained controversial. We report the results from lineage-tracing experiments in chicken and mouse embryos aimed to provide information of the dynamics of Mullerian duct formation. We show that all Mullerian duct components derive from the coelomic epithelium in both species. Our data support a model of a Mullerian epithelial tube derived from an epithelial anlage at the mesonephros anterior end, which then segregates from the epithelium and extends caudal of its own accord, via a process involving rapid cell proliferation. This tube is surrounded by mesenchymal cells derived from local delamination of coelomic epithelium. We exclude any significant influx of cells from the Wolffian duct and also the view of a tube forming by coelomic epithelium invagination along the mesonephros. Our data provide clues of the underlying mechanism of tubulogenesis relevant to both normal and abnormal development of the female reproductive tract. (c) 2006 Elsevier Inc. All rights reserved.