THE ANALGESIC PROPERTIES OF NUMORPHAN (14-HYDROXY DIHYDROMORPHINONE) - A NEW SYNTHETIC NARCOTIC
THE ANALGESIC PROPERTIES OF NUMORPHAN (14-HYDROXY DIHYDROMORPHINONE) - A NEW SYNTHETIC NARCOTIC
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DOI：
10.1056/nejm195610112551504
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发表时间：
1956-01-01
影响因子：
158.5
通讯作者：
BIERMAN, HR
中科院分区：
文献类型：
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作者：
COBLENTZ, A;BIERMAN, HR
Numorphan（14-羟基二氢吗啡酮）是一种合成麻醉剂，在200例肿瘤性疾病患者中，剂量为1至5 mg时是一种迅速有效的镇痛剂。对不依赖麻醉药的癌症患者，尤其是与阿托品合用，是一种有效的术前用药。在1至5 mg剂量范围内未观察到不良副作用。无恶心、呕吐和便秘。尽管大剂量（6-20毫克）和长期给药的癌症患者成瘾的其他麻醉品，特异质没有遇到任何年龄组。
Numorphan (14-hydroxy dihydromorphinone), a synthetic narcotic, was a promptly effective analgesic in doses of 1 to 5 mg in 200 patients with neoplastic diseases. It was an efficacious preopera-tive medication, especially in combination with atropine, in patients with cancer without addiction to narcotics. No untoward side effects were observed within the dose range of 1 to 5 mg. Absence of nausea, vomiting and constipation was notable. Despite large doses (6-20 mg) and prolonged administration to patients with cancer addicted to other narcotics, idiosyncrasy was not encountered in any age group.