Antibiotic Resistance of Helicobacter Pylori Isolated in the Southeast Coastal Region of China
Antibiotic Resistance of Helicobacter Pylori Isolated in the Southeast Coastal Region of China
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DOI：
10.1111/hel.12046
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发表时间：
2013-08-01
期刊：
影响因子：
4.4
通讯作者：
Zhang, Jianzhong
中科院分区：
文献类型：
--
作者：
Su, Peng;Li, Youming;Zhang, Jianzhong
背景幽门螺杆菌（H.pylori）对抗生素的耐药性在全球范围内不断增加，降低了其在当前根除治疗中的疗效。本研究评估了中国东南沿海地区幽门螺杆菌对抗生素的耐药性，并提出了适当的替代方案。资料与方法2010 - 2012年，从我国东南沿海两省8个地区采集幽门螺杆菌菌株17731株。采用琼脂稀释法测定了这些菌株对6种抗生素的耐药性。结果对克拉霉素、甲硝唑、左氧氟沙星、阿莫西林、庆大霉素和呋喃唑酮的耐药率分别为21.5%、95.4%、20.6%、0.1%、0.1%和0.1%。2倍、3倍和4倍耐药率分别为25.5%、7.5%和0.1%。左氧氟沙星耐药率与克拉霉素耐药率呈正相关，与甲硝唑耐药率呈负相关。结论我国东南沿海地区幽门螺杆菌对克拉霉素、甲硝唑、左氧氟沙星及多种抗生素耐药率较高。治疗的选择应根据该国这一地区的药敏试验进行个体化。
Background The resistance of Helicobacter pylori (H.pylori) to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies. This study evaluated H.pylori resistance to antibiotics in the southeast coastal region of China and suggests appropriate alternatives. Materials and Methods Seventeen thousand seven hundred and thirty one H.pylori strains were collected from eight areas of two provinces in coastal southeast China from 2010 to 2012. The resistance of these strains to six antibiotics was tested using the agar dilution method. Results The resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, gentamicin and furazolidone were 21.5, 95.4, 20.6, 0.1, 0.1 and 0.1%, respectively. Double, triple and quadruple antibacterial resistant percentages were 25.5, 7.5 and 0.1%, respectively. A positive association between the resistance to levofloxacin and to clarithromycin was found, but there was a negative correlation in the resistances to levofloxacin and to metronidazole. Conclusions The prevalence of H.pylori resistance to clarithromycin, metronidazole, levofloxacin and multiple antibiotics in coastal southeast China is high. Choice of therapy should be individualized based on a susceptibility test in this region of the country.