Therapeutic efficacy of selective intra-arterial chemoradiotherapy with docetaxel and nedaplatin for fixed bulky nodal disease in head and neck cancer of unknown primary
Therapeutic efficacy of selective intra-arterial chemoradiotherapy with docetaxel and nedaplatin for fixed bulky nodal disease in head and neck cancer of unknown primary
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多西紫杉醇和奈达铂选择性动脉内放化疗治疗原发灶不明的头颈癌固定性大块淋巴结病的疗效
DOI：
10.1007/s00405-021-07121-9
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发表时间：
2022
影响因子：
2.6
通讯作者：
Murayama Sadayuki
中科院分区：
文献类型：
--
作者：
Heianna Joichi;Makino Wataru;Hirakawa Hitoshi;Agena Shinya;Tomita Hayato;Ariga Takuro;Ishikawa Kazuki;Takehara Shota;Maemoto Hitoshi;Murayama Sadayuki
PurposeFixed bulky nodal disease in patients with head and neck cancer of unknown primary（HNCUP）remains difficult to treat. This retrospective study evaluated the therapeutic efficacy of selective intraarterial chemoradiotherapy with docetaxel and nedaplatin for fixed bulky nodal disease in HNCUP.MethodsData from 7 continuous patients with fixed bulky nodal disease in HNCUP who had undertaken selective intraarterial chemoradiotherapy were analyzed.对整个咽粘膜和所有双侧淋巴结区域进行照射（总剂量50戈伊），并对大体积淋巴结病变提供额外的20戈伊。动脉内化疗使用奈达铂（80 mg/m2）和多西他赛（60 mg/m2）联合治疗。结果指标为局部控制、无病生存期、总生存期和不良事件。使用Kaplan-Meier方法进行统计分析。结果中位随访期为24个月（范围9-64）。所有患者在影像学和临床表现上均有囊外扩张（N3 b）。由于巨大的疾病的症状是颈部不适（100%），肿瘤出血（43%），气管阻塞（14%）和颈动脉窦综合征（28%）。宫颈病变最大直径的中位数为84 mm（范围70-107），3年局部控制率、无病生存率和总生存率分别为100%、54%和64%。动脉内放化疗后，所有患者因巨大病变引起的症状均消失。2例患者（28%）发生4级白细胞减少症，为急性不良事件。没有其他严重的急性不良事件observed.ConclusionSelective动脉内放化疗与多西他赛和奈达铂可以潜在地实现良好的局部控制和生存在HNCUP与固定的巨大淋巴结疾病。
PurposeFixed bulky nodal disease in patients with head and neck cancer of unknown primary (HNCUP) remains difficult to treat. This retrospective study evaluated the therapeutic efficacy of selective intra-arterial chemoradiotherapy with docetaxel and nedaplatin for fixed bulky nodal disease in HNCUP.MethodsData from seven consecutive patients with fixed bulky nodal disease in HNCUP who had undergone selective intra-arterial chemoradiotherapy were analyzed. Whole pharyngeal mucosa and all bilateral nodal areas were irradiated (total dose 50 Gy), and bulky nodal lesions were provided an additional 20 Gy. Intra-arterial chemotherapy used a combination of nedaplatin (80 mg/m2) and docetaxel (60 mg/m2). Outcome measures were local control, disease-free survival, overall survival, and adverse events. Statistical analyses were performed using the Kaplan–Meier method.ResultsMedian follow-up period was 24 months (range 9–64). All patients had extracapsular extension (N3b) on imaging and clinical findings. Symptoms due to bulky disease were neck discomfort (100%), tumor bleeding (43%), tracheal obstruction (14%), and carotid sinus syndrome (28%). Median value for maximum diameter of cervical disease was 84 mm (range 70–107), and 3-year local control, disease-free survival, and overall survival rates were 100, 54, and 64%, respectively. Symptoms due to bulky disease disappeared in all patients after intra-arterial chemoradiotherapy. Grade 4 leukopenia occurred in two patients (28%) as an acute adverse event. No other serious acute adverse events were observed.ConclusionSelective intra-arterial chemoradiotherapy with docetaxel and nedaplatin can potentially achieve both favorable local control and survival in in HNCUP with fixed bulky nodal disease.
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DOI：
10.1016/j.ijrobp.2009.04.011
发表时间：
2010-04
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Eisbruch A;Harris J;Garden AS;Chao CK;Straube W;Harari PM;Sanguineti G;Jones CU;Bosch WR;Ang KK
通讯作者：
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DOI：
10.1023/a:1008360323986
发表时间：
1999
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
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作者：
P. Schöffski;G. Catimel;A. Planting;J. Droz;J. Verweij;D. Schrijvers;L. Gras;A. Schrijvers;J. Wanders;A. Hanauske
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喉癌同侧颈部和对侧颈部转移瘤的囊外扩散
DOI：
10.1177/000348940211100510
发表时间：
2002
期刊：
Annals of Otology, Rhinology and Laryngology
影响因子：
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作者：
Y. Suoğlu;Burak Erdamar;M. Karatay;O. Katircioǧlu;T. Sunay
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T. Sunay
影响因子：
2.6
作者：
Chan, Jimmy Yu Wai;To, Victor Shing Howe;Wei, William Ignace
通讯作者：
Wei, William Ignace
影响因子：
4.8
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Kobayashi, Wataru;Teh, Beng Gwan;Nagahata, Morio
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