Characterization of porous injectable poly-(propylene fumarate)-based bone graft substitute
Characterization of porous injectable poly-(propylene fumarate)-based bone graft substitute
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DOI：
10.1002/jbm.a.31633
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发表时间：
2008-06-15
影响因子：
4.9
通讯作者：
Yaszemski, Michael J.
中科院分区：
文献类型：
--
作者：
Kim, Choll W.;Talac, Robert;Yaszemski, Michael J.
在过去的十年中，骨移植物在骨科应用中的使用稳步增加。随着手术技术的进步，加上需要骨科治疗的老年人口不断增加，对骨移植替代品的需求也随之增加。为了在临床上有用，骨移植替代物必须是生物相容的、生物可吸收的，并且具有方便的处理特性。此外，它必须具有允许细胞向内生长和重塑的微结构，同时提供机械强度。聚（富马酸丙二醇酯）（PPF）已被研究作为一种可注射的，可生物降解的骨科应用支架。产生多孔互连聚合物支架的各种方法是可用的。发泡技术是完成这一任务的方便方法。碳酸氢盐和弱酸之间的反应产生CO2气体，在聚合过程中引起起泡反应。该技术允许调节支架的孔隙率。图像分析和机械测试的多孔PPF制造使用发泡技术表明，可以产生一个高度多孔，互连的支架。在接近50%的孔隙率下，该支架具有优异的处理性能，含有50至500 μ m的孔径，弹性模量为20至40 MPa。发泡技术提供了一种额外的方法，通过该方法可以制造用于各种骨组织工程应用的临床有用的聚合物。(C)2007 Wiley Periodicals，Inc.
The use of bone grafts for orthopedic applications have increased steadily over the past decade. With improvements in surgical technique, combined with an increasing aged population requiring orthopedic treatment, the need for bone grafts substitutes have also increased. To be useful clinically, the bone graft substitute must be biocompatible, bioabsorbable, and have convenient handling properties. In addition, it must possess a microarchitecture that allows cellular ingrowth and remodeling while simultaneously providing mechanical strength. Poly(propylene fumarate) (PPF) has been investigated as an injectable, biodegradable scaffold for orthopedic applications. Various methods to create a porous, interconnected polymer scaffold are available. The foaming technique is a convenient method to accomplish this task. Reactions between bicarbonate salts and weak acids generate CO2 gas, causing a bubbling reaction during the polymerization process. This technique allows the porosity of the scaffold to be modulated. Image analysis and mechanical testing of porous PPF fabricated using the foaming technique shows that a highly porous, interconnected scaffold can be produced. At similar to 50% porosity, the scaffold has excellent handling properties, contains pore sizes ranging from 50 to 500 mu m with an elastic modulus ranging from 20 to 40 MPa. The foaming technique provides an additional method by which clinically useful polymers can be fabricated for use in various bone tissue engineering applications. (C) 2007 Wiley Periodicals, Inc.